4.2.3.98: (+)-T-muurolol synthase
This is an abbreviated version!
For detailed information about (+)-T-muurolol synthase, go to the full flat file.
Reaction
Synonyms
SCLAV_p0068, SSCG_03688
ECTree
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Systematic Name
Systematic Name on EC 4.2.3.98 - (+)-T-muurolol synthase
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(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-T-muurolol-forming)
The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original 1-pro-S hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T-muurolol.