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4.2.3.98: (+)-T-muurolol synthase

This is an abbreviated version!
For detailed information about (+)-T-muurolol synthase, go to the full flat file.

Reaction

(2E,6E)-farnesyl diphosphate
+
H2O
=
(+)-T-muurolol
+
diphosphate

Synonyms

SCLAV_p0068, SSCG_03688

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.98 (+)-T-muurolol synthase

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Resultsin table
10AA Sequence
1Cloned(Commentary)
2KM Value [mM]
2Organism
3Reaction
2Reference
4Substrates and Products (Substrate)
4Synonyms
1Systematic Name
2Turnover Number [1/s]

Systematic Name

Systematic Name on EC 4.2.3.98 - (+)-T-muurolol synthase

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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-T-muurolol-forming)
The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original 1-pro-S hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T-muurolol.