4.2.3.87: alpha-guaiene synthase

This is an abbreviated version!
For detailed information about alpha-guaiene synthase, go to the full flat file.

Reaction

Synonyms

Pat177, patchoulol synthase, PTS, TPS, TPS24, VIT_19s0014g02590, VvGuaS, VvTPS24

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.87 alpha-guaiene synthase

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Results	in table
5	AA Sequence
4	Cloned(Commentary)
1	Expression
3	General Information
1	Inhibitors
1	KM Value [mM]
2	Metals/Ions
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
5	Organism
1	pH Optimum
1	pH Range
10	Protein Variants
2	Purification (Commentary)
1	Reaction
5	Reference
6	Source Tissue
5	Substrates and Products (Substrate)
2	Subunits
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.3.87 - alpha-guaiene synthase

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(2Z,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, alpha-guaiene-forming)

Requires Mg2+. The enzyme from Pogostemon cablin gives 13% alpha-guaiene as well as 37% (-)-patchoulol (see EC 4.2.3.70), 13% delta-guaiene (see EC 4.2.3.93), and traces of at least ten other sesquiterpenoids [1]. In Aquilaria crassna three clones of the enzyme gave about 80% delta-guaiene and 20% alpha-guaiene, with traces of alpha-humulene. A fourth clone gave 54% delta-guaiene and 45% alpha-guaiene [2].