4.2.3.75: (-)-germacrene D synthase
This is an abbreviated version!
For detailed information about (-)-germacrene D synthase, go to the full flat file.
Word Map on EC 4.2.3.75
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4.2.3.75
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cyclization
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sesquiterpene
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cyclases
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carbocation
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geranyl
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epi-isozizaene
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limonene
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chemodiversity
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spearmint
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remold
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4s-limonene
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aristolochene
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oleoresin
- 4.2.3.75
-
cyclization
-
sesquiterpene
- cyclases
-
carbocation
-
geranyl
- epi-isozizaene
- limonene
-
chemodiversity
- spearmint
-
remold
-
4s-limonene
- aristolochene
-
oleoresin
Reaction
Synonyms
(-)-germacrene D synthase, Cop4, GDS, GerD, germacrene D synthase, Sc19, terpenoid cyclase, TPS, TPS07, TPS1, VitiM1610, ylangene/germacrene synthase
ECTree
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Metals Ions
Metals Ions on EC 4.2.3.75 - (-)-germacrene D synthase
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K+
-
replacement of Mg2+ by Mn2+ results in loss of product beta-copaene. Presence of K+ decreases the (?)-germacrene D yield and instead increases the overall yield of tricyclic sesquiterpene olefins
Mg2+
Mn2+
-
replacement of Mg2+ by Mn2+ results in loss of product beta-copaene. In the presence of the Mn2+, Cop4 favors a reaction path that ends after one cyclization in (?)-germacrene D
Mg2+
required. Bi-dentate Mg2+-binding by residue 303 is not obligatory