4.2.3.72: alpha-gurjunene synthase

This is an abbreviated version!
For detailed information about alpha-gurjunene synthase, go to the full flat file.

Reaction

Synonyms

GUR

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.72 alpha-gurjunene synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	AA Sequence
1	Cloned(Commentary)
2	Expression
1	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
2	Organism
1	pH Optimum
1	pI Value
1	Purification (Commentary)
1	Reaction
2	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Substrates and Products (Substrate)
2	Subunits
1	Synonyms
1	Systematic Name

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 4.2.3.72 - alpha-gurjunene synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(2E,6E)-farnesyl diphosphate

(-)-alpha-gurjunene + diphosphate

Solidago canadensis

-

initial step is the formation of a germacrenyl cation after abstraction of the diphosphate group. Internal shifts of electron pairs lead to the patchoulenyl cation, which then undergoes a double 1,2-hydride shift. Rearrangement leads to the aromadendrenyl cation, which then undergoes a 1,2-hydride shift. Abstraction of a proton by the enzyme yields isoledene, which is reprotonated at the active site of the enzyme. At this junction two proton abstractions are possible, one leading to (-)-alpha-gurjunene and the other to (+)-gamma-gurjunene

710992

product ratio 91% (-)-alpha-gurjunene and 9% (+)-gamma-gurjunene

-

?

(2E,6E)-farnesyl diphosphate

alpha-gurjunene + diphosphate

Taiwania cryptomerioides

-

-

747920

-

-

?

additional information

?

-

Taiwania cryptomerioides

-

no activity with geranyl diphosphate and geranylgeranyl diphosphate

747920

-

-

?