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4.2.3.7: pentalenene synthase

This is an abbreviated version!
For detailed information about pentalenene synthase, go to the full flat file.

Word Map on EC 4.2.3.7

Reaction

(2E,6E)-farnesyl diphosphate
=
pentalenene
 +
diphosphate

Synonyms

EC 4.6.1.5, PenA, pentalenene synthase, pentalenene synthetase, synthetase, pentalenene

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.7 pentalenene synthase

Engineering

Engineering on EC 4.2.3.7 - pentalenene synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D80E
the mutation influences binding of the required divalent Mg2+ cofactor
D81E
the mutation influences binding of the required divalent Mg2+ cofactor
D84E
the mutation influences binding of the required divalent Mg2+ cofactor
H309A
H309C
H309F
H309S
N219A
catalytically inactive
N219D
N219L
W308F
W308F/H309F
reaction products are pentalene plus varying proportions of (+)-germacrene A
D84E
-
the mutation influences binding of the required divalent Mg2+ cofactor
-
H309A
-
the mutant exhibits nearly full wild type activity
-
H309C
-
the mutant exhibits nearly full wild type activity
-
H309F
-
the mutant exhibits nearly full wild type activity
-
H309S
-
the mutant exhibits nearly full wild type activity
-