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4.2.3.6: trichodiene synthase

This is an abbreviated version!
For detailed information about trichodiene synthase, go to the full flat file.

Word Map on EC 4.2.3.6

Reaction

(2E,6E)-farnesyl diphosphate
=
trichodiene
 +
diphosphate

Synonyms

EC 4.1.99.6, sesquiterpene cyclase, synthase, trichodiene, TDN synthase, trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase, tri5, trichodiene synthase, trichodiene synthetase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.6 trichodiene synthase

Crystallization

Crystallization on EC 4.2.3.6 - trichodiene synthase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystallized by the hanging drop vapor diffusion method, in complex with Mg2+, PPi, the benzyl triethylammonium cation, at a resolution of 2.85 A
-
mutant D100E and its complex with diphosphate
recombinant enzyme, both unliganded and in complex with diphosphate
the structures of the mutants are solved at resolutions ranging from 2.1 to 2.7 A
X-ray crystal structures of mutant R304K and its complexes with diphosphate and aza analogues of the bisabolyl carbocation intermediate
X-ray structures of the Y305F and D100E mutants and their complexes with diphosphate and aza analogues of the bisabolyl carbocation intermediate