4.2.3.57: (-)-beta-caryophyllene synthase
This is an abbreviated version!
For detailed information about (-)-beta-caryophyllene synthase, go to the full flat file.
Word Map on EC 4.2.3.57
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4.2.3.57
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sesquiterpene
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terpene
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e-beta-caryophyllene
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enemies
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diabrotica
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herbivore-induced
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virgifera
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biofuel production
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agriculture
- 4.2.3.57
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sesquiterpene
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terpene
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e-beta-caryophyllene
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enemies
- diabrotica
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herbivore-induced
- virgifera
- biofuel production
- agriculture
Reaction
Synonyms
(E)-beta-caryophyllene synthase, alpha-humulene/(-)-(E)-beta-caryophyllene synthase, At5g23960, BCS, beta-caryophyllene synthase, CarS, E-(beta)-caryophyllene synthase, EbetaC synthase, GwECar2, More, OkBCS, PnCPS, PnTPS1, QHS1, RtTPS1, RtTPS3, TPS04, TPS1, TPS21, tps23, TPS3
ECTree
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General Information
General Information on EC 4.2.3.57 - (-)-beta-caryophyllene synthase
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evolution
metabolism
physiological function
additional information
isozyme RtTPS1 contains all the conserved domains of the TPS family, including the RR(P)X8W, RXR, and DDXXD (X is any amino acid) motifs, and absolutely conserved arginine, cysteine and histidine residues in active-site
evolution
isozyme RtTPS3 contains all the conserved domains of the TPS family, including the RR(P)X8W, RXR, and DDXXD (X is any amino acid) motifs, and absolutely conserved arginine, cysteine and histidine residues in active-site
evolution
the cyclization process catalyzed by PnTPSs follows a 1,10-closure mechanism assuming that the present PnTPSs have evolved from a common ancestor
evolution
the enzyme belongs to typical class of sesquiterpene synthases from angiosperms, clade TPS-a. Across five Ocimum species, OkBCS shows the highest expression in Ocimum kilimandscharicum followed by Ocimum americanum, Ocimum tenuiflorum, and Ocimum gratissimum while Ocimum basilicum hadve trace levels
beta-caryophyllene is produced via the mevalonate (MVA)-mediated pathway, overview
metabolism
beta-caryophyllene is produced via the mevalonate (MVA)-mediated pathway, overview
metabolism
GC/MS profiling of terpenes from immature black pepper fruit, accumulation of beta-caryophyllene, the major sesquiterpene in peppercorn, changes from 46% to 70% as fruits ripen
metabolism
putative alpha-pinene and beta-caryophyllene biosynthesis pathway
flowers of plant lines lacking (E)-beta-caryophyllene emission show greater bacterial growth on their stigmas than wild-type flowers, and their seeds are lighter and misshapen. Plant lines with ectopic (E)-beta-caryophyllene emission from vegetative parts are more resistant than wild-type plants to pathogen infection of leaves, and show reduced cell damage and higher seed production. (E)-beta-caryophyllene seems to act by direct inhibition of bacterial growth
physiological function
agro-infiltration based transient expression manipulation with OkBCS overexpression and silencing confirms its role in beta-caryophyllene biosynthesis
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isozymes RtTPS1-4 mainly produce (+)-alpha-pinene and (+)-beta-pinene, as well as small amounts of (-)-alpha-pinene and (-)-beta-pinene with GPP, while RtTPS1 and RtTPS3 are also active with FPP, producing beta-caryophyllene (65.71% for RtTPS1 and 93.05% for RtTPS3), along with a smaller amount of alpha-humulene (4.29% for RtTPS1 and 6.95% for RtTPS3). alpha/beta-Pinene, beta-caryophyllene, and alpha-humulene constitute the major active components in Rhodomyrtus tomentosa. Among them, (+)-alpha-pinene and beta-caryophyllene are most abundant in the leaves
additional information
isozymes RtTPS1-4 mainly produce (+)-alpha-pinene and (+)-beta-pinene, as well as small amounts of (-)-alpha-pinene and (-)-beta-pinene with GPP, while RtTPS1 and RtTPS3 are also active with FPP, producing beta-caryophyllene (65.71% for RtTPS1 and 93.05% for RtTPS3), along with a smaller amount of alpha-humulene (4.29% for RtTPS1 and 6.95% for RtTPS3). alpha/beta-Pinene, beta-caryophyllene, and alpha-humulene constitute the major active components in Rhodomyrtus tomentosa. Among them, (+)-alpha-pinene and beta-caryophyllene are most abundant in the leaves
additional information
isozymes RtTPS1-4 mainly produce (+)-alpha-pinene and (+)-beta-pinene, as well as small amounts of (-)-alpha-pinene and (-)-beta-pinene with GPP, while RtTPS1 and RtTPS3 are also active with FPP, producing beta-caryophyllene (65.71% for RtTPS1 and 93.05% for RtTPS3), along with a smaller amount of alpha-humulene (4.29% for RtTPS1 and 6.95% for RtTPS3). alpha/beta-Pinene, beta-caryophyllene, and alpha-humulene constitute the major active components in Rhodomyrtus tomentosa. Among them, (+)-alpha-pinene and beta-caryophyllene are most abundant in the leaves