4.2.3.50: (+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]

This is an abbreviated version!
For detailed information about (+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing], go to the full flat file.

Reaction

Synonyms

SBS

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.50 (+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	Natural Substrates/ Products (Substrates)
1	Organism
2	Pathway
1	Purification (Commentary)
2	Reaction
1	Reference
1	Source Tissue
3	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 4.2.3.50 - (+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Substrate/Product Search

(2Z,6Z)-farnesyl diphosphate

(+)-alpha-santalene + (+)-endo-beta-bergamotene + (-)-endo-alpha-bergamotene + (-)-exo-alpha-bergamotene + (-)-epi-beta-santalene

Solanum habrochaites

B8XA41

because (2Z,6Z)-farnesyl diphosphate is not commercially available, in vitro enzymatic assays with both (2Z,6Z)-farnesyl diphosphate synthase and and SBS recombinant proteins are conducted using isopentenyl diphosphate and dimethylallyl diphosphate as substrates. No activity with geranyl diphosphate, (2E,6E)-farnesyl diphosphate, and (2E,6E,10E)-geranylgeranyl diphosphate. Multiproduct cyclization pathway for the cyclization of (2Z,6Z)-farnesyl diphosphate to class II sesquiterpenes by SBS: following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the Z,Z-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-alpha-santalene and (-)-epi-beta-santalene, while the (6S)-bisabolyl cation will give rise to (-)-exo-alpha-bergamotene, (-)-endo-alpha-bergamotene, and (+)-endo-beta-bergamotene

706218

(2Z,6Z)-farnesyl diphosphate

(+)-alpha-santalene + diphosphate

Solanum habrochaites

B8XA41

involved in sesquiterpene biosynthesis. The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-alpha-santalene, while the (6S)-bisabolyl cation will give rise to (-)-endo-alpha-bergamotene and (+)-endo-beta-bergamotene. Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation

706218

additional information

Solanum habrochaites

B8XA41

the enzyme is able to use neryl diphosphate and transform it into a product whose mass spectrum matches that of alpha-terpineol

706218