Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.2.3.5: chorismate synthase

This is an abbreviated version!
For detailed information about chorismate synthase, go to the full flat file.

Word Map on EC 4.2.3.5

Reaction

5-O-(1-carboxyvinyl)-3-phosphoshikimate
=
chorismate
 +
phosphate

Synonyms

5-enolpyruvylshikimate-3-phosphate phospholyase, 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate lyase, ARO2, aroC, aroF, chorismate synthase, chorismate synthetase, CS, CS1, CS2, EC 4.6.1.4, MtCS, VEG216, Vegetative protein 216, Vlaro2

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.5 chorismate synthase

Inhibitors

Inhibitors on EC 4.2.3.5 - chorismate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(17beta)-17-(4-hydroxybenzoyl)androsta-3,5-diene-3-carboxylic acid
-
(2E)-5,7-dihydroxy-2-[[4-(pyrrolidin-1-yl)phenyl]methylidene]-1-benzofuran-3(2H)-one
-
(2E)-5,7-dihydroxy-2-[[4-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-3(2H)-one
-
(2E)-6,7-dihydroxy-2-([2-hydroxy-4-[(6-hydroxyhexyl)oxy]phenyl]methylidene)-1-benzofuran-3(2H)-one
-
(3R,4R,5R)-5-(carboxymethoxy)-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
-
(3R,4S,5R)-4-hydroxy-3-[(2S)-1-hydroxy-1-oxo-2-phosphonooxypropan-2-yl]oxy-5-phosphonooxycyclohexene-1-carboxylic acid
-
(3R,4S,5R)-5-(1-carboxyethoxy)-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
-
(3R,4S,5R)-5-[(1R)-1-carboxy-1-phosphonoethoxy]-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
-
(3R,4S,5S,6S)-5-(1-carboxyethenoxy)-6-fluoro-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
-
(6R)-6-fluoro-5-enoylpyruvylshikimate 3-phosphate
-
IC50 is 0.0005 mM when the enzyme is preincubated with the inhibitor, the IC50 is 0.25 mM when the enzyme is not preincubated with the inhibitor, inhibition is not absolutely irreversible
(6S)-6-fluoro-5-enolpyruvylshikimate 3-phosphate
-
competitive inhibitor
([1,1'-biphenyl]-4-yl)(4-nitrophenyl)methanone
-
1-(naphthalen-2-yl)-2-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]ethan-1-one
-
2-difluoro-[1-phosphonooxyethoxy]-4-hydroxy-3-phosphonooxycyclohexene-1-carboxylic acid
-
3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid
-
4-[(E)-(5,7-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]benzoic acid
-
4-[7-(hydroxymethyl)-1-benzofuran-2-yl]-7-methyl-2-oxo-2H-1-benzopyran-6-yl furan-2-carboxylate
-
4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
-
6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
-
bathophenanthroline
-
-
diethyl dicarbonate
-
-
dioxygen
-
inactivation
N-(2-benzoyl-3-methyl-1-benzofuran-6-yl)-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanamide
-
N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
-
N-[2-(4-methoxybenzoyl)-3-methyl-1-benzofuran-5-yl]-2-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)acetamide
-
N-[5-(1,1-dioxo-1lambda6,2-thiazolidin-2-yl)-1H-indazol-3-yl]-2-[4-(piperidin-1-yl)phenyl]acetamide
-
O2
-
activity only in anaerobic conditions