4.2.3.5: chorismate synthase

This is an abbreviated version!
For detailed information about chorismate synthase, go to the full flat file.

Word Map on EC 4.2.3.5

4.2.3.5

flavin

dahps

7-phosphate

3-deoxy-d-arabino-heptulosonate

sempervirens

dehydroquinate

corydalis

drug development

Reaction

Synonyms

5-enolpyruvylshikimate-3-phosphate phospholyase, 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate lyase, ARO2, aroC, aroF, chorismate synthase, chorismate synthetase, CS, CS1, CS2, EC 4.6.1.4, MtCS, VEG216, Vegetative protein 216, Vlaro2

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.5 chorismate synthase

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Results	in table
1	Activating Compound
43157	AA Sequence
1	Application
1	CAS Registry Number
23	Cloned(Commentary)
46	Cofactor
9	Crystallization (Commentary)
1	Expression
2	General Information
3	General Stability
1	IC50 Value
42	Inhibitors
35	Ki Value [mM]
17	KM Value [mM]
2	Localization
1	Metals/Ions
35	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
75	Organism
6	Pathway
42	PDB ID
9	pH Optimum
6	pI Value
3	Posttranslational Modification
9	Protein Variants
17	Purification (Commentary)
9	Reaction
8	Reaction Type
74	Reference
7	Source Tissue
19	Specific Activity [micromol/min/mg]
7	Storage Stability
87	Substrates and Products (Substrate)
35	Subunits
37	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Cloned

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Cloned on EC 4.2.3.5 - chorismate synthase

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3 entries

cloning and expression in Escherichia coli strain Rosetta(DE3) in the absence of IPTG induction, heterologous overexpression of the MtCS protein

Mycobacterium tuberculosis

691478

expressed in Escherichia coli strains BL21(DE3) and DV1017 (the latter lacks chorismate synthase activity)

2 entries

expressed in Saccharomyces cerevisiae

Verticillium longisporum

C8Z2I6

701862

expression in a chorismate synthase deficient Saccharomyces cerevisiae strain

7 entries

expression in Escherichia coli

4 entries

mutant proteins are heterologously expressed in Escherichia coli, strain BL21(DE3)RP

Neurospora crassa

692285

overexpression in Escherichia coli

2 entries

overexpression in Escherichia coli, fused with an eight-residue C-terminal tag

Helicobacter pylori

649228