4.2.3.46: alpha-farnesene synthase
This is an abbreviated version!
For detailed information about alpha-farnesene synthase, go to the full flat file.
Word Map on EC 4.2.3.46
Reaction
Synonyms
(E,E)-alpha-farnesene synthase, AdAFS1, AFS, AFS-1, AFS1, alpha farnesene synthase 1, alpha-farnesene synthase, alpha-farnesene synthase-1, E,E-alpha-farnesene synthase, MdAFS1, sesquiterpene synthase, TPS02, TPS03, TPS2, Tps7
ECTree
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Metals Ions on EC 4.2.3.46 - alpha-farnesene synthase
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METALS and IONS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
K+
Mg2+
Mn2+
K+
MdAFS1 retains up to 12% of its activity in the absence of K+, enzyme contains K+ binding region, MdAFS1 exhibits a type II K+ response, MdAFS1 is not absolutely dependent upon M+ its unequivocal classification as type I or type II K+ activated, or that of any other terpene synthases, will not be possibl, then type I enzymes can exhibit type II kinetics and vice versa.
K+
30-50 mM, enhances activity 5fold. Km: 3 mM. Addition of K+ reduces monoterpene synthase activity
K+
activity is dependent on K+, the potassium binding region is defined
K+
-
in presence of 50 mM potassium, the enzyme activity increases 15fold as compared to the activity in an assay devoid of potassium
Mg2+
Km: 0.248 mM, divalent cation required, preference for Mg2+. Maximal velocities with Mn2+ is about 50% of that with Mg2+
Mn2+
KM: about 0.02 mM, divalent cation required, preference for Mg2+. Maximal velocities with Mn2+ is about 50% of that with Mg2+
