4.2.3.4: 3-dehydroquinate synthase
This is an abbreviated version!
For detailed information about 3-dehydroquinate synthase, go to the full flat file.
Word Map on EC 4.2.3.4
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4.2.3.4
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shikimate
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dahp
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3-deoxy-d-arabino-heptulosonate
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chorismate
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pentafunctional
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3-phosphoshikimate
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3-dehydroquinase
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1-carboxyvinyltransferase
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drug development
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medicine
- 4.2.3.4
- shikimate
- dahp
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3-deoxy-d-arabino-heptulosonate
- chorismate
-
pentafunctional
- 3-phosphoshikimate
- 3-dehydroquinase
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1-carboxyvinyltransferase
- drug development
- medicine
Reaction
Synonyms
3-dehydroquinate synthase, 3-dehydroquinate synthetase, 3-dehydroquinic acid synthetase, 5-dehydroquinate synthase, 5-dehydroquinic acid synthetase, aroB, dehydroquinate synthase, dehydroquinate synthetase, DHQ synthase, DHQS, EC 4.6.1.3, hpDHQS, synthase, 5-dehydroquinate, Xoo1243
ECTree
4.2.3.4 3-dehydroquinate synthaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 4.2.3.4 - 3-dehydroquinate synthase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
7-deoxysedoheptulose
competitive, inhibitor can be taken up by the fructose ABC-transporter
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alpha-(2,6-anhydro-3-deoxy-D-arabino-heptulopyranosid)onate 7-phosphonate
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chlorogenic acid
X6Q997
competitive, inhibits the carbon-oxygen lyase activity of DHQS, and also inhibits the growth of Providencia alcalifaciens, Moraxella catarrhalis, Staphylococcus aureus, and Escherichia coli with MIC values of 60 to 100 microM. In the presence of aromatic amino acids supplied externally, chlorogenic acid does not show the toxic effect
[(1R)-(1alpha,3beta,4alpha ,5beta)]-5-(2-phosphonoethyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid
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[(1R)-(1alpha,3beta,4alpha,5beta)]-1,4,5-trihydroxy-3-(phosphonooxy)-cyclohexane-1-carboxylate
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[(1R)-(1alpha,3beta,4alpha,5beta)]-5-(E)-(2-phosphonoethenyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid
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[(1R)-(1alpha,3beta,4alpha,5beta)]-5-(phosphonomethyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid
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slow binding inhibitor
[(1R)-(1alpha,3beta,4alpha,5beta)]-5-(Z)-(2-phosphonoethenyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid
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[(2R)-(2alpha,4beta,5alpha,6beta)]-6-(2-phosphonoethyl)-2,4,5-trihydroxytetrahydropyran-2-carboxylate
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[(2R)-(2alpha,4beta,5alpha,6beta)]-6-(phosphonomethyl)-2,4,5-trihydroxytetrahydropyran-2-carboxylate
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EDTA
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treatment of the Co2+-holoenzyme with EDTA in the absence of substrate results in the rapid loss of catalytic activity
EDTA
0.1 mM, complete loss of activity. Addition of Co2+, Zn2+ and Ca2+ leads to, respectively, full, 43% and 38% recovery of the enzyme activity
EDTA
inactivates the enzyme, and enzyme activity is restored by several divalent metal ions including (in order of decreasing effectiveness) Cd2+, Co2+, Zn2+, and Mn2+
