4.2.3.38: alpha-bisabolene synthase

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For detailed information about alpha-bisabolene synthase, go to the full flat file.

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Synonyms

(E)-alpha-bisabolene synthase, apha-bisabolene synthase, beta-bisabolene synthase, BIS, bisabolene synthase, E-alpha-bisabolene synthase, GbTPS2, More, TPS2, TPS3

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.38 alpha-bisabolene synthase

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Results	in table
1	Activating Compound
7	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
6	Inhibitors
3	kcat/KM [mM/s]
5	KM Value [mM]
5	Metals/Ions
1	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
7	Organism
5	Pathway
6	PDB ID
1	pH Optimum
2	pI Value
4	Purification (Commentary)
2	Reaction
7	Reference
12	Source Tissue
11	Substrates and Products (Substrate)
4	Subunits
14	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.3.38 - alpha-bisabolene synthase

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SYSTEMATIC NAME

IUBMB Comments

(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming]

This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC 4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding.