4.2.3.32: levopimaradiene synthase
This is an abbreviated version!
For detailed information about levopimaradiene synthase, go to the full flat file.
Word Map on EC 4.2.3.32
Reaction
Synonyms
abietadiene synthase, levopimaradiene/abietadiene synthase, LP synthase, LPS, More, PaLAS, TPS-LAS
ECTree
4.2.3.32 levopimaradiene synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.3.32 - levopimaradiene synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(+)-copalyl-diphosphate
(-)-abietadiene + levopimaradiene + neoabietadiene + palustradiene + diphosphate
(+)-copalyl-diphosphate
13-hydroxy-8(14)-abietene + diphosphate
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the initial products formed and released in vitro are unstable alcohols identified as epimeric thermally unstable allylic tertiary alcohols, 13-hydroxy-8(14)-abietene. The dehydration of the alcohol products, yielding the well established diterpene products levopimaradiene, abietadiene, neoabietadiene, and palustradiene, occurs due to the conditions of the GC-MS analysis typically used
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?
(+)-copalyl-diphosphate
levopimaradiene + diphosphate
reaction intermediate is labdadienyl diphosphate
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?
(+)-copalyl diphosphate
abieta-8(14),12-diene + diphosphate
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products are levopimaradiene, abieta-7,13-diene, and sandaracopimaradiene
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?
(+)-copalyl-diphosphate
(-)-abietadiene + levopimaradiene + neoabietadiene + palustradiene + diphosphate
reaction intermediate is C8-sandaracopimaradienyl cation
bifunctional levopimaradiene/abietadiene synthase produces a mixture of diterpenes
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?
(+)-copalyl-diphosphate
(-)-abietadiene + levopimaradiene + neoabietadiene + palustradiene + diphosphate
reaction intermediate is C8-sandaracopimaradienyl cation
bifunctional levopimaradiene/abietadiene synthase, about 47% levopimaradiene, 27% abietadiene, 22% neoabietadiene, 3% palustradiene
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?
additional information
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catalyzes an intermediate step in synthesis of ginkgolide A
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?
additional information
?
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catalyzes an intermediate step in synthesis of ginkgolide A
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?
additional information
?
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abietadiene synthase (PaLAS) is a bifunctional terpene synthase that catalyzes both class I and class II reactions, i.e. formation of (+)-copalyl diphosphate from geranylgeranyl diphosphate (cf. EC 5.5.1.12, class II diTPS), and formation of abieta-8(14),12-diene from (+)-copalyl diphosphate (EC 4.2.3.32, class I diTPS)
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