4.2.3.23: germacrene-A synthase

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For detailed information about germacrene-A synthase, go to the full flat file.

Reaction

Synonyms

(+)-(10R)-germacrene A synthase, (+)-germacrene A synthase, FENS, GAS, GAS1, GAS2, GASlo, GASsh, germacrene A synthase, germacrene A synthase 1, germacrene A synthase 2, guaiadiene synthase, NS1, Sc1, sesquiterpene cyclase, sesquiterpene synthase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.23 germacrene-A synthase

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Results	in table
1	Activating Compound
32	AA Sequence
2	Application
1	CAS Registry Number
14	Cloned(Commentary)
1	Cofactor
1	Expression
1	General Stability
2	Inhibitors
2	kcat/KM [mM/s]
18	KM Value [mM]
4	Localization
5	Metals/Ions
11	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
21	Organism
7	Pathway
10	pH Optimum
1	pH Range
4	pI Value
1	Posttranslational Modification
14	Protein Variants
8	Purification (Commentary)
3	Reaction
19	Reference
29	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
34	Substrates and Products (Substrate)
15	Subunits
31	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
8	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.3.23 - germacrene-A synthase

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SYSTEMATIC NAME

IUBMB Comments

(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]

Requires Mg2+ for activity. While germacrene A is an enzyme-bound intermediate in the biosynthesis of a number of phytoalexins, e.g. EC 4.2.3.9 (aristolochene synthase) from some species and EC 4.2.3.21 (vetispiradiene synthase), it is the sole sesquiterpenoid product formed in chicory [1].