4.2.3.22: germacradienol synthase

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Word Map on EC 4.2.3.22

4.2.3.22

cyclases

meroterpenoids

prenyltransferase

dmapp

camphene

humulene

copalyl

Reaction

(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol

Synonyms

Cyc2, germacradienol synthase, germacradienol/geosmin synthase, germacradienol/germacrene D synthase, germacrene D synthase, GS, sesquiterpene synthase, spterp13, terpene cyclase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.22 germacradienol synthase

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Results	in table
16	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
3	Inhibitors
1	kcat/KM [mM/s]
4	KM Value [mM]
18	Metals/Ions
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
103	Organism
4	Pathway
3	PDB ID
4	pH Optimum
2	pH Range
3	Protein Variants
3	Purification (Commentary)
5	Reaction
5	Reaction Type
11	Reference
2	Renatured (Commentary)
2	Source Tissue
21	Substrates and Products (Substrate)
3	Subunits
16	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
4	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 4.2.3.22 - germacradienol synthase

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cell culture

Streptomyces peucetius

B0FLN6

strain ATCC 27952 produces clinically important anthracycline chemotherapeutic agents of the polyketide class of antibiotics, daunorubicin and doxorubicin