4.2.3.18: abieta-7,13-diene synthase
This is an abbreviated version!
For detailed information about abieta-7,13-diene synthase, go to the full flat file.
Reaction
Synonyms
(-)-abietadiene synthase, abietadiene cyclase, abietadiene synthase, abietadiene/levopimaradiene synthase, AGAS, cyclase, abietadiene, PaLAS, PdABS, PtTPS-LAS, TPS-LAS
ECTree
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Reaction
Reaction on EC 4.2.3.18 - abieta-7,13-diene synthase
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(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate
reactions leading from intermediate abieta-8(14)-en-13-yl cation to product are driven by the electrostatic effect of the ionized diphopshate group
(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate
gas-phase and enzyme-free post-transition state direct dynamics simulation gas-phase reveal that abietadiene synthase must intervene in order to produce abietadiene selectively, steering this reaction to avoid the generation of a sevenmembered ring containing product which is formed in the enzyme-free reaction
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(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate
reaction mechanism proceeds via water quenching of the abieta-8(14)-en-13-yl carbocation, resulting in 13-hydroxy-8(14)-abietene
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