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4.2.3.16: (4S)-limonene synthase

This is an abbreviated version!
For detailed information about (4S)-limonene synthase, go to the full flat file.

Word Map on EC 4.2.3.16

Reaction

geranyl diphosphate
=
(S)-limonene
 +
diphosphate

Synonyms

(-)-limonene synthase, (4S)-LS, ag9, CsTPS1, EC 4.1.99.10, limonene synthase, LS, MsLS, PsTPS-Lim

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.16 (4S)-limonene synthase

Reference

topprint

Reference on EC 4.2.3.16 - (4S)-limonene synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Croteau, R.; Alonso, W.R.; Koepp, A.E.; Shim, J.H.; Cane, D.E.
Irreversible inactivation of monoterpene cyclases by a mechanism-based inhibitor
Arch. Biochem. Biophys.
307
397-404
1993
Mentha sp.
Manually annotated by BRENDA team
Bohlmann, J.; Steele C.L.; Croteau, R.
Monoterpene synthases from grand fir (Abies grandis): cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase
J. Biol. Chem.
272
21784-21792
1997
Abies grandis (O22340), Abies grandis
Manually annotated by BRENDA team
Colby, S.M.; Alonso, W.R.; Katahira, E.J.; McGarvey, D.J.; Croteau, R.
4S-limonene synthase from the oil glands of spearmint (Mentha spicata): cDNA isolation, characterization, and bacterial expression of the catalytically active monoterpene cyclase
J. Biol. Chem.
268
23016-23024
1993
Mentha sp.
Manually annotated by BRENDA team
Yuba, A.; Yazaki, K.; Tabata, M.; Honda, G.; Croteau, R.
cDNA cloning, characterization, ana functional expression of 4S-(-)-limonene synthase from Perilla frutescens
Arch. Biochem. Biophys.
332
280-287
1996
Perilla frutescens
Manually annotated by BRENDA team
Alonso, W.R.; Rajaonarivony, J.I.M.; Gershenzon, J.; Croteau, R.
Purification of 4S-limonene synthase, a monoterpene cyclase from the glandular trichomes pf peppermint (Mentha x piperita) and spearmint (Mentha spicata)
J. Biol. Chem.
267
7582-7587
1992
Mentha sp.
Manually annotated by BRENDA team
Rajaonarivony, J.I.M.; Gershenzon, J.; Croteau, R.
Characterization and mechanism of (4S)-limonene synthase, a monoterpene cyclase from the glandular trichomes of peppermint (Mentha x piperita)
Arch. Biochem. Biophys.
296
49-57
1992
Mentha sp.
Manually annotated by BRENDA team
Alonso, W.R.; Crock, J.E.; Cotreau, R.
Production and characterization of polyclonal antibodies in rabbits to 4S-limonene synthase from spearmint (Mentha spicata)
Arch. Biochem. Biophys.
301
58-63
1993
Mentha sp.
Manually annotated by BRENDA team
Adam, K.P.; Crock, J.; Croteau, R.
Partial purification and characterization of a monoterpene cyclase, limonene synthase, from the liverwort Ricciocarpos natans
Arch. Biochem. Biophys.
332
352-356
1996
Ricciocarpos natans
Manually annotated by BRENDA team
Turner, G.; Gershenzon, J.; Nielson, E.E.; Froehlich, J.E.; Croteau, R.
Limonene synthase, the enzyme responsible for monoterpene biosynthesis in peppermint, is localized to leucoplasts of the oil gland secretory cells
Plant Physiol.
120
879-886
1999
Mentha sp.
Manually annotated by BRENDA team
Rajaonarivony, J.I.M.; Gershenzon, J.; Miyazaki, J.; Croteau, R.
Evidence for an essential histidine residue in 4S-limonene synthase and other terpene cyclases
Arch. Biochem. Biophys.
299
77-82
1992
Mentha sp.
Manually annotated by BRENDA team
Maruyama, T.; Ito, M.; Kiuchi, F.; Honda, G.
Molecular cloning, functional expression and characterization of D-limonene synthase from Schizonepeta tenuifolia
Biol. Pharm. Bull.
24
373-377
2001
Agastache rugosa
Manually annotated by BRENDA team
Schwab, W.; Williams, D.C.; Davis, E.M.; Croteau, R.
Mechanism of monoterpene cyclization: Stereochemical aspects of the transformation of noncyclizable substrate analogs by recombinant (-)-limonene synthase, (+)-bornyl diphosphate synthase, and (-)-pinene synthase
Arch. Biochem. Biophys.
392
123-136
2001
Mentha spicata
Manually annotated by BRENDA team
Katoh S.;Hyatt D.;Croteau R.
Altering product outcome in Abies grandis (-)-limonene synthase and (-)-limonene/(-)-alpha-pinene synthase by domain swapping and directed mutagenesis
Arch. Biochem. Biophys.
425
65-76
2004
Abies grandis
Manually annotated by BRENDA team
Schwab W.;Williams DC, Croteau R.
Mechanism of monoterpene cyclization: stereochemistry of the transformation of noncyclizable substrate analogs by recombinant (-)-limonene synthase, (+)-bornyl diphosphate synthase, and (-)-pinene synthase
J. Mol. Catal. B
19
415-421
2002
Mentha spicata
-
Manually annotated by BRENDA team
Martin, D.M.; Faeldt, J.; Bohlmann, J.
Functional characterization of nine Norway spruce TPS genes and evolution of gymnosperm terpene synthases of the TPS-d subfamily
Plant Physiol.
135
1908-1927
2004
Picea abies (Q675L1), Picea abies
Manually annotated by BRENDA team
Gunnewich, N.; Page, J.E.; Kollner, T.G.; Degenhardt, J.; Kutchan, T.M.
Functional expression and characterization of trichome-specific (-)-limonene synthase and (+)-alpha-pinene synthase from Cannabis sativa
Nat. Prod. Commun.
2
223-232
2007
Cannabis sativa
-
Manually annotated by BRENDA team
Byun-McKay, A.; Godard, K.A.; Toudefallah, M.; Martin, D.M.; Alfaro, R.; King, J.; Bohlmann, J.; Plant, A.L.
Wound-induced terpene synthase gene expression in Sitka spruce that exhibit resistance or susceptibility to attack by the white pine weevil
Plant Physiol.
140
1009-1021
2006
Picea sitchensis (Q20HU7), Picea sitchensis
Manually annotated by BRENDA team
Hyatt, D.C.; Youn, B.; Zhao, Y.; Santhamma, B.; Coates, R.M.; Croteau, R.B.; Kang, C.
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis
Proc. Natl. Acad. Sci. USA
104
5360-5365
2007
Mentha spicata
Manually annotated by BRENDA team
Munoz-Bertomeu, J.; Ros, R.; Arrillaga, I.; Segura, J.
Expression of spearmint limonene synthase in transgenic spike lavender results in an altered monoterpene composition in developing leaves
Metab. Eng.
10
166-177
2008
Mentha spicata
Manually annotated by BRENDA team
Bohlmann, J.; Phillips, M.; Ramachandiran, V.; Katoh, S.; Croteau, R.
cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis)
Arch. Biochem. Biophys.
368
232-243
1999
Abies grandis (Q9M7D0)
Manually annotated by BRENDA team
Ohara, K.; Matsunaga, E.; Nanto, K.; Yamamoto, K.; Sasaki, K.; Ebinuma, H.; Yazaki, K.
Monoterpene engineering in a woody plant Eucalyptus camaldulensis using a limonene synthase cDNA
Plant Biotechnol. J.
8
28-37
2010
Perilla frutescens
Manually annotated by BRENDA team
Dolzhenko, Y.; Bertea, C.M.; Occhipinti, A.; Bossi, S.; Maffei, M.E.
UV-B modulates the interplay between terpenoids and flavonoids in peppermint (Mentha x piperita L.)
J. Photochem. Photobiol. B Biol.
100
67-75
2010
Mentha x piperita
Manually annotated by BRENDA team
Alonso-Gutierrez, J.; Chan, R.; Batth, T.S.; Adams, P.D.; Keasling, J.D.; Petzold, C.J.; Lee, T.S.
Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production
Metab. Eng.
19
33-41
2013
Mentha spicata
Manually annotated by BRENDA team
Fukushima, A.; Nakamura, M.; Suzuki, H.; Saito, K.; Yamazaki, M.
High-throughput sequencing and de novo assembly of red and green forms of the Perilla frutescens var. crispa transcriptome
PLoS ONE
10
e0129154
2015
Perilla frutescens var. crispa
Manually annotated by BRENDA team