4.2.3.156: hydroxysqualene synthase

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For detailed information about hydroxysqualene synthase, go to the full flat file.

Reaction

Synonyms

Acel_1693, hpnC, RPA3743, ZMO0869

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.156 hydroxysqualene synthase

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Results	in table
26	AA Sequence
2	Cloned(Commentary)
2	General Information
4	Natural Substrates/ Products (Substrates)
8	Organism
1	Pathway
1	Reaction
8	Reference
16	Substrates and Products (Substrate)
11	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 4.2.3.156 - hydroxysqualene synthase

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SYSTEMATIC NAME

IUBMB Comments

presqualene diphosphate diphosphate-lyase (adding water; hydroxyasqualene-forming)

This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 1.17.8.1, hydroxysqualene dehydroxylase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.