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4.2.3.156: hydroxysqualene synthase

This is an abbreviated version!
For detailed information about hydroxysqualene synthase, go to the full flat file.

Reaction

presqualene diphosphate
+
H2O
=
hydroxysqualene
+
diphosphate

Synonyms

Acel_1693, hpnC, RPA3743, ZMO0869

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.156 hydroxysqualene synthase

Reference

Reference on EC 4.2.3.156 - hydroxysqualene synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pan, J.J.; Solbiati, J.O.; Ramamoorthy, G.; Hillerich, B.S.; Seidel, R.D.; Cronan, J.E.; Almo, S.C.; Poulter, C.D.
Biosynthesis of squalene from farnesyl diphosphate in bacteria: three steps catalyzed by three enzymes
ACS Cent. Sci.
1
77-82
2015
Zymomonas mobilis (Q5NP67), Rhodopseudomonas palustris (Q6N3F1), Rhodopseudomonas palustris ATCC BAA-98 (Q6N3F1), Zymomonas mobilis ZM4 (Q5NP67)
Manually annotated by BRENDA team
Pan, J.J.; Ramamoorthy, G.; Poulter, C.D.
Absolute configuration of hydroxysqualene. An intermediate in bacterial hopanoid biosynthesis
Org. Lett.
18
512-515
2016
Rhodopseudomonas palustris, Zymomonas mobilis, Acidothermus cellulolyticus (A0LVK5), Acidothermus cellulolyticus ATCC 43068 (A0LVK5)
Manually annotated by BRENDA team