4.2.3.152: 2-epi-5-epi-valiolone synthase
This is an abbreviated version!
For detailed information about 2-epi-5-epi-valiolone synthase, go to the full flat file.
Word Map on EC 4.2.3.152
-
4.2.3.152
-
cyclization
-
synthases
-
acarbose
-
validamycin
-
lividans
-
hygroscopicus
-
actinoplanes
-
in-frame
-
aminocyclitol
-
sunscreen
-
mycosporine-like
-
albus
-
symbiotic
-
cyanobacteria
-
cyclases
-
nitrogen-fixing
-
alpha-glucosidase
-
cosmid
-
cyclitols
-
valienamine
-
dinoflagellate
-
actinomyces
-
3-dehydroquinate
- 4.2.3.152
-
cyclization
- synthases
- acarbose
- validamycin
- lividans
- hygroscopicus
- actinoplanes
-
in-frame
-
aminocyclitol
-
sunscreen
-
mycosporine-like
- albus
-
symbiotic
- cyanobacteria
- cyclases
-
nitrogen-fixing
- alpha-glucosidase
-
cosmid
-
cyclitols
- valienamine
-
dinoflagellate
- actinomyces
- 3-dehydroquinate
Reaction
Synonyms
AbcC, AcbC, C7-cyclitol synthase, CetA, EVS, SalQ, sedoheptulose 7-phosphate cyclase, SH7PC, ValA
ECTree
Advanced search results
Systematic Name
Systematic Name on EC 4.2.3.152 - 2-epi-5-epi-valiolone synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
alpha-D-sedoheptulopyranose 7-phosphate phosphate-lyase (cyclizing; 2-epi-5-epi-valiolone-forming)
The enzyme is highly specific for alpha-D-sedoheptulopyranose 7-phosphate. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. The enzyme is involved in the biosynthesis of C7N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A. cf. EC 4.2.3.155, 2-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase.