4.2.3.141: sclareol synthase

This is an abbreviated version!
For detailed information about sclareol synthase, go to the full flat file.

Reaction

Synonyms

EC 3.1.7.4, sclareol synthase, SsSS

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.141 sclareol synthase

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Results	in table
1	AA Sequence
2	Application
3	Cloned(Commentary)
6	General Information
3	kcat/KM [mM/s]
3	KM Value [mM]
2	Localization
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
5	Organism
3	Pathway
1	pH Optimum
8	Protein Variants
1	Purification (Commentary)
2	Reaction
4	Reference
10	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.2.3.141 - sclareol synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O

(13R)-sclareol + diphosphate

2 entries

(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O

sclareol + diphosphate

Salvia sclarea

K4HYB0

-

748907, 749408

-

-

?

(9S,10S)-copalyl diphosphate + H2O

manool + diphosphate

Salvia sclarea

K4HYB0

-

719185

-

-

?

labda-13-en-8-ol diphosphate + H2O

sclareol + diphosphate

Salvia sclarea

K4HYB0

-

719185

-

-

?

additional information

?

-

7 entries

(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O

(13R)-sclareol + diphosphate

Salvia sclarea

K4HYB0

i.e. 8alpha-hydroxy-copalyl diphosphate

746584

-

-

?

(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O

(13R)-sclareol + diphosphate

Salvia sclarea

K4HYB0

i.e. 8alpha-hydroxy-copalyl diphosphate, the enzyme shows strong stereoselectivity in formation of the (13R)-epimer, residue N431 is responsible

746584

-

-

?

additional information

?

-

Salvia sclarea

-

in coupled enzyme assays with labda-13-en-8-ol diphosphate synthase, sclareol is the major product with minor amounts of manool, manoyl oxides and epi-manoyl oxide as secondary products

719185

-

-

?

additional information

?

-

Salvia sclarea

K4HYB0

in coupled enzyme assays with labda-13-en-8-ol diphosphate synthase, sclareol is the major product with minor amounts of manool, manoyl oxides and epi-manoyl oxide as secondary products

719185

-

-

?

additional information

?

-

Salvia sclarea

-

no substrate: geranylgeranyl diphosphate

719185

-

-

?

additional information

?

-

Salvia sclarea

K4HYB0

no substrate: geranylgeranyl diphosphate

719185

-

-

?

additional information

?

-

Salvia sclarea

K4HYB0

GC-MS reaction product analysis

748907

-

-

?

additional information

?

-

Salvia sclarea

K4HYB0

GC-MS reaction product analysis. Molecular docking of enzyme products in to the active site of the enzyme, modeling, overview

746584

-

-

?

additional information

?

-

Salvia sclarea

-

GC-MS reaction product analysis. Molecular docking of enzyme products in to the active site of the enzyme, modeling, overview

746584

-

-

?