4.2.3.132: neoabietadiene synthase
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For detailed information about neoabietadiene synthase, go to the full flat file.
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Synonyms
abietadiene synthase, abietadiene/levopimaradiene synthase, AGAS, NAS, PtTPS-LAS, TPS-LAS
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Systematic Name
Systematic Name on EC 4.2.3.132 - neoabietadiene synthase
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(+)-copaly-diphosphate diphosphate-lyase (cyclizing, neoabietadiene-forming)
Isolated from Abies grandis (grand fir) [1]. This class I enzyme forms about equal proportions of abietadiene, levopimaradiene and neoabietadiene. See also EC 4.2.3.18, abieta-7,13-diene synthase and EC 4.2.3.32, levopimaradiene synthase. An X-ray study of this multifunctional enzyme showed that the class I activity is in the alpha domain, while (+)-copalyl diphosphate synthase activity (EC 5.5.1.12, a class II activity) is in the beta and gamma domains [2]. In Pinus taeda (loblolly pine) the major product is levopimaradiene, with less abietadiene and neoabietadiene [3].