4.2.3.125: alpha-muurolene synthase
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For detailed information about alpha-muurolene synthase, go to the full flat file.
Reaction
Synonyms
Cop3
ECTree
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Substrates Products
Substrates Products on EC 4.2.3.125 - alpha-muurolene synthase
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REACTION DIAGRAM
(2E,6E)-farnesyl diphosphate
alpha-muurolene + diphosphate
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recombinant Escherichia coli produces alpha-muurolene to 30% of total terpenoid compounds, but also other sesquiterpenes
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(2E,6E)-farnesyl diphosphate
alpha-muurolene + diphosphate
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the major cyclization products of Cop3 and its loop mutants are derived from an E,E-germacradienyl cation formed after ionization and 1,10 cyclization of E,E-farnesyl diphosphate. alpha-Muurolene is 30% of the products formed from (2E,6E)-farnesyl diphosphate
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(2E,6E)-farnesyl diphosphate
alpha-muurolene + diphosphate
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recombinant Escherichia coli produces alpha-muurolene to 30% of total terpenoid compounds, but also other sesquiterpenes
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?
?
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product profiling by GC-MS analysis, overview. alpha-Muurolene is the major terpenoid compound detected in Cop3 cultures, accounting for about 30% of the total sesquiterpenes detected. Significant amounts of beta-elemene, gamma-muurolene, germacrene D, and delta-cadinene are synthesized in the headspace of Cop3 cultures
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additional information
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product profiling by GC-MS analysis, overview. alpha-Muurolene is the major terpenoid compound detected in Cop3 cultures, accounting for about 30% of the total sesquiterpenes detected. Significant amounts of beta-elemene, gamma-muurolene, germacrene D, and delta-cadinene are synthesized in the headspace of Cop3 cultures
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additional information
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seven different sesquiterpenes products, wild-type Cop3 also shows gamma-muurolene synthase activity, EC 4.2.3.126, and produces 12% gamma-muurolene and 35% gemacrene A, product of germacrene A synthase, EC 4.2.3.23, of total products from (2E,6E)-farnesyl diphosphate, product profiling by GC-MS analysis, overview
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additional information
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product profiling by GC-MS analysis, overview. alpha-Muurolene is the major terpenoid compound detected in Cop3 cultures, accounting for about 30% of the total sesquiterpenes detected. Significant amounts of beta-elemene, gamma-muurolene, germacrene D, and delta-cadinene are synthesized in the headspace of Cop3 cultures
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