4.2.3.124: 2-deoxy-scyllo-inosose synthase

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For detailed information about 2-deoxy-scyllo-inosose synthase, go to the full flat file.

Word Map on EC 4.2.3.124

4.2.3.124

aminoglycoside

circulans

2-deoxystreptamine-containing

2-deoxystreptamine

carbocycle

butirosin

aminocyclitols

dehydroquinate

butirosin-producing

aglycon

kanamycin

neomycin

tobramycin

actinomycete

gentamicin

nad+

catechol

tenebrarius

cyclization

micromonospora

amacs

aminoglycoside-aminocyclitols

benzenoid

shikimate

industry

Reaction

Synonyms

AlloH, btrC, BtrC2, DOI synthase, DOIS, KanA, kanC, neoC, tbmA

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.124 2-deoxy-scyllo-inosose synthase

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Results	in table
21	AA Sequence
2	Application
15	Cloned(Commentary)
16	Cofactor
2	Crystallization (Commentary)
2	Expression
48	General Information
2	IC50 Value
14	Inhibitors
6	kcat/KM [mM/s]
1	Ki Value [mM]
11	KM Value [mM]
19	Metals/Ions
13	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
131	Organism
8	Pathway
9	pH Optimum
12	Protein Variants
7	Purification (Commentary)
14	Reaction
40	Reference
3	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
51	Substrates and Products (Substrate)
11	Subunits
54	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
2	Temperature Stability [°C]
9	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.3.124 - 2-deoxy-scyllo-inosose synthase

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D-glucose-6-phosphate phosphate-lyase (2-deoxy-scyllo-inosose-forming)

Requires Co2+ [2]. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Requires an NAD+ cofactor, which is transiently reduced during the reaction [1,4]. The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex [6,7].