4.2.3.124: 2-deoxy-scyllo-inosose synthase
This is an abbreviated version!
For detailed information about 2-deoxy-scyllo-inosose synthase, go to the full flat file.
Word Map on EC 4.2.3.124
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4.2.3.124
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aminoglycoside
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circulans
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2-deoxystreptamine-containing
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2-deoxystreptamine
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carbocycle
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butirosin
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aminocyclitols
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dehydroquinate
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butirosin-producing
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aglycon
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kanamycin
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neomycin
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tobramycin
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actinomycete
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gentamicin
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nad+
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catechol
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tenebrarius
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cyclization
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micromonospora
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amacs
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aminoglycoside-aminocyclitols
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benzenoid
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shikimate
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industry
- 4.2.3.124
- aminoglycoside
- circulans
-
2-deoxystreptamine-containing
- 2-deoxystreptamine
-
carbocycle
- butirosin
-
aminocyclitols
- dehydroquinate
-
butirosin-producing
-
aglycon
- kanamycin
- neomycin
- tobramycin
-
actinomycete
- gentamicin
- nad+
- catechol
- tenebrarius
-
cyclization
- micromonospora
-
amacs
- aminoglycoside-aminocyclitols
-
benzenoid
- shikimate
- industry
Reaction
Synonyms
AlloH, btrC, BtrC2, DOI synthase, DOIS, KanA, kanC, neoC, tbmA
ECTree
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Inhibitors
Inhibitors on EC 4.2.3.124 - 2-deoxy-scyllo-inosose synthase
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carbaglucose-6-phosphate
a substrate analogue inhibitor, binding structure, overview. The inhibitor coordinates a cobalt ion in the active site
D-glucose 6-homophosphonate
competitive inhibition versus D-glucose 6-phosphate
D-glucose 6-phosphonate
competitive inhibition versus D-glucose 6-phosphate, hydride transfer from 6-phosphonate to NAD+
DL-carbaglucose 6-phosphate
a mechanism-based irreversible inhibitor, synthesis, overview. The alpha,beta-unsaturated intermediate traps a specific nucleophilic group in the active site through the Michael-type 1,4-addition. The covalently modified amino acid residue is Lys141