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4.2.3.124: 2-deoxy-scyllo-inosose synthase

This is an abbreviated version!
For detailed information about 2-deoxy-scyllo-inosose synthase, go to the full flat file.

Word Map on EC 4.2.3.124

Reaction

D-glucose 6-phosphate
=
2-deoxy-L-scyllo-inosose
+
phosphate

Synonyms

AlloH, btrC, BtrC2, DOI synthase, DOIS, KanA, kanC, neoC, tbmA

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.124 2-deoxy-scyllo-inosose synthase

Inhibitors

Inhibitors on EC 4.2.3.124 - 2-deoxy-scyllo-inosose synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
carbaglucose-6-phosphate
a substrate analogue inhibitor, binding structure, overview. The inhibitor coordinates a cobalt ion in the active site
D-glucose 6-homophosphonate
competitive inhibition versus D-glucose 6-phosphate
D-glucose 6-phosphonate
competitive inhibition versus D-glucose 6-phosphate, hydride transfer from 6-phosphonate to NAD+
DL-carbaglucose 6-phosphate
a mechanism-based irreversible inhibitor, synthesis, overview. The alpha,beta-unsaturated intermediate traps a specific nucleophilic group in the active site through the Michael-type 1,4-addition. The covalently modified amino acid residue is Lys141
glucose-6-phosphonate
-