4.2.3.12: 6-pyruvoyltetrahydropterin synthase
This is an abbreviated version!
For detailed information about 6-pyruvoyltetrahydropterin synthase, go to the full flat file.
Word Map on EC 4.2.3.12
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4.2.3.12
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phosphatases
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protein-tyrosine
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phosphotyrosine
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src
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hyperphenylalaninemia
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bh4
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sepiapterin
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orthovanadate
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dual-specificity
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cyclohydrolase
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tcptp
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dihydropteridine
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vanadate
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receptor-like
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receptor-type
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phenylarsine
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rfviii
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pterins
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ptp-pest
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ptp-1b
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5-hydroxytryptophan
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sulfenic
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pteridines
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ptpalpha
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phosphotyrosyl
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tyrosine-specific
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thoracotomy
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phenylketonuria
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medicine
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ptpro
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gtpch
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haemophilia
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substrate-trapping
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dystonia
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pervanadate
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non-receptor
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csk
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antigen-related
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ptpn22
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cdc25
- 4.2.3.12
- phosphatases
-
protein-tyrosine
- phosphotyrosine
- src
- hyperphenylalaninemia
- bh4
- sepiapterin
- orthovanadate
-
dual-specificity
-
cyclohydrolase
- tcptp
- dihydropteridine
- vanadate
-
receptor-like
-
receptor-type
-
phenylarsine
-
rfviii
- pterins
- ptp-pest
- ptp-1b
- 5-hydroxytryptophan
-
sulfenic
- pteridines
- ptpalpha
-
phosphotyrosyl
-
tyrosine-specific
-
thoracotomy
- phenylketonuria
- medicine
- ptpro
- gtpch
- haemophilia
-
substrate-trapping
- dystonia
- pervanadate
-
non-receptor
- csk
-
antigen-related
- ptpn22
- cdc25
Reaction
Synonyms
2-amino-4-oxo-6-(erythro-1',2',3'-trihydroxypropyl)-7,8-dihydroxypterdine triphosphate lyase, 6-(1,2-dioxopropyl)tetrahydropterin synthase, 6-carboxy-5,6,7,8-tetrahydropterin synthase, 6-pyruvoyl tetrahydrobiopterin synthase, 6-pyruvoyl-tetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase paralog, 6-pyruvoyltetrahydropterin synthase [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [25-glutamine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase-like protein, EC 4.6.1.10, ePTPS, PH0634, PPH4 synthase, PPH4S, protein purple, PTP synthase, PTPS, PTPS homologue, PTPS-III, PTS, pyruvoyltetrahydropterin synthase, SCO 6650, synthase, 6-pyruvoyltetrahydropterin, synthase, 6-pyruvoyltetrahydropterin [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [25-glutamine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [87-leucine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit)
ECTree
4.2.3.12 6-pyruvoyltetrahydropterin synthaseAdvanced search results
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results (Specific Activity
Specific Activity on EC 4.2.3.12 - 6-pyruvoyltetrahydropterin synthase
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SPECIFIC ACTIVITY [µmol/min/mg] 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
0.0253 - 0.0255
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pH 7.4, 37ºC, no differences observed in the enzyme activity between pregnant and non-pregnant women
0.12
additional information
additional information
in cells treated with mixed inflammatory cytokines IFNgamma, TNFalpha and IL-1, PTPS messenger RNA abundance and enzyme activity are 10fold and 3fold higher than in untreated cells, respectively
additional information
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in cells treated with mixed inflammatory cytokines IFNgamma, TNFalpha and IL-1, PTPS messenger RNA abundance and enzyme activity are 10fold and 3fold higher than in untreated cells, respectively
additional information
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10fold more Flag-tag fused PTPS per total protein in cytoplasm compared to nucleus, no activity of Flag-tag fused PTPS in the nucleus
additional information
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5.3 pmol/min/10*10 platelets, PTPS activity does not change significantly after treatment with glucocorticoids in a dose equivalent to at least 100 mg prednisone for at least 7 days, enzyme assays at 37°C
additional information
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1.4 mU/mg in brain determined with the ONPG-assay with the o-nitrophenyl-beta-D-glactopyranoside substrate of a mouse heterozygous for the Pts-lacZ allele (encoding a fusion protein of N-terminal 35 amino acids of 6-pyruvoyl-tetrahydropterin synthase and beta-galactosidase), 1 U is defined as 1 OD at 420 nm per minute at pH 7.5 and 37°C
additional information
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2.2 mU/mg in liver determined with the ONPG-assay with the o-nitrophenyl-beta-D-glactopyranoside substrate of a mouse heterozygous for the Pts-lacZ allele (encoding a fusion protein of N-terminal 35 amino acids of 6-pyruvoyl-tetrahydropterin synthase and beta-galactosidase), 1 U is defined as 1 OD at 420 nm per minute at pH 7.5 and 37°C
additional information
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3.5 mU/mg in liver determined with the ONPG-assay with the o-nitrophenyl-beta-D-glactopyranoside substrate of a mouse homozygous for the Pts-lacZ allele (encoding a fusion protein of N-terminal 35 amino acids of 6-pyruvoyl-tetrahydropterin synthase and beta-galactosidase), 1 U is defined as 1 OD at 420 nm per minute at pH 7.5 and 37°C
