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4.2.3.12: 6-pyruvoyltetrahydropterin synthase

This is an abbreviated version!
For detailed information about 6-pyruvoyltetrahydropterin synthase, go to the full flat file.

Word Map on EC 4.2.3.12

Reaction

7,8-dihydroneopterin 3'-triphosphate
=
6-pyruvoyl-5,6,7,8-tetrahydropterin
 +
Triphosphate

Synonyms

2-amino-4-oxo-6-(erythro-1',2',3'-trihydroxypropyl)-7,8-dihydroxypterdine triphosphate lyase, 6-(1,2-dioxopropyl)tetrahydropterin synthase, 6-carboxy-5,6,7,8-tetrahydropterin synthase, 6-pyruvoyl tetrahydrobiopterin synthase, 6-pyruvoyl-tetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase paralog, 6-pyruvoyltetrahydropterin synthase [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [25-glutamine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase-like protein, EC 4.6.1.10, ePTPS, PH0634, PPH4 synthase, PPH4S, protein purple, PTP synthase, PTPS, PTPS homologue, PTPS-III, PTS, pyruvoyltetrahydropterin synthase, SCO 6650, synthase, 6-pyruvoyltetrahydropterin, synthase, 6-pyruvoyltetrahydropterin [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [25-glutamine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [87-leucine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit)

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.12 6-pyruvoyltetrahydropterin synthase

Source Tissue

Source Tissue on EC 4.2.3.12 - 6-pyruvoyltetrahydropterin synthase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
tissue from normal pregnant women
Manually annotated by BRENDA team
-
monkey kidney cells, CRL 1650
Manually annotated by BRENDA team
-
larvae
Manually annotated by BRENDA team
-
cells from patients with BH4 deficiency
Manually annotated by BRENDA team
-
in kidney very weak beta-galactosidase expression in adult and strong expression in newborn mice heterozygous for the Pts-lacZ allele (encoding a fusion protein of N-terminal 35 amino acids of 6-pyruvoyl-tetrahydropterin synthase and beta-galactosidase). Localization in the cytoplasm but not in the nucleus in all cells lining the proximal convoluted tube in adult and newborn mice. No staining in the medulla of newborn mice. Nuclear localization in the thin limb of the Henle loops in adult mice
Manually annotated by BRENDA team
acute lymphoblastic leukemia cell line, 65% homology with rat enzyme
Manually annotated by BRENDA team
-
heat instability, it is present in the anterior pituitary endothelial cells but not in posterior pituitary
Manually annotated by BRENDA team
-
neuroblastoma cells, CRL 2271
Manually annotated by BRENDA team