4.2.3.12: 6-pyruvoyltetrahydropterin synthase
This is an abbreviated version!
For detailed information about 6-pyruvoyltetrahydropterin synthase, go to the full flat file.
Word Map on EC 4.2.3.12
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4.2.3.12
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phosphatases
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protein-tyrosine
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phosphotyrosine
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src
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hyperphenylalaninemia
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bh4
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sepiapterin
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orthovanadate
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dual-specificity
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cyclohydrolase
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tcptp
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dihydropteridine
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vanadate
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receptor-like
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receptor-type
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phenylarsine
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rfviii
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pterins
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ptp-pest
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ptp-1b
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5-hydroxytryptophan
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sulfenic
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pteridines
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ptpalpha
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phosphotyrosyl
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tyrosine-specific
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thoracotomy
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phenylketonuria
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medicine
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ptpro
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gtpch
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haemophilia
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substrate-trapping
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dystonia
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pervanadate
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non-receptor
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csk
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antigen-related
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ptpn22
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cdc25
- 4.2.3.12
- phosphatases
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protein-tyrosine
- phosphotyrosine
- src
- hyperphenylalaninemia
- bh4
- sepiapterin
- orthovanadate
-
dual-specificity
-
cyclohydrolase
- tcptp
- dihydropteridine
- vanadate
-
receptor-like
-
receptor-type
-
phenylarsine
-
rfviii
- pterins
- ptp-pest
- ptp-1b
- 5-hydroxytryptophan
-
sulfenic
- pteridines
- ptpalpha
-
phosphotyrosyl
-
tyrosine-specific
-
thoracotomy
- phenylketonuria
- medicine
- ptpro
- gtpch
- haemophilia
-
substrate-trapping
- dystonia
- pervanadate
-
non-receptor
- csk
-
antigen-related
- ptpn22
- cdc25
Reaction
Synonyms
2-amino-4-oxo-6-(erythro-1',2',3'-trihydroxypropyl)-7,8-dihydroxypterdine triphosphate lyase, 6-(1,2-dioxopropyl)tetrahydropterin synthase, 6-carboxy-5,6,7,8-tetrahydropterin synthase, 6-pyruvoyl tetrahydrobiopterin synthase, 6-pyruvoyl-tetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase paralog, 6-pyruvoyltetrahydropterin synthase [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [25-glutamine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase-like protein, EC 4.6.1.10, ePTPS, PH0634, PPH4 synthase, PPH4S, protein purple, PTP synthase, PTPS, PTPS homologue, PTPS-III, PTS, pyruvoyltetrahydropterin synthase, SCO 6650, synthase, 6-pyruvoyltetrahydropterin, synthase, 6-pyruvoyltetrahydropterin [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [25-glutamine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [87-leucine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit)
ECTree
4.2.3.12 6-pyruvoyltetrahydropterin synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.2.3.12 - 6-pyruvoyltetrahydropterin synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
?
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the second of the three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP
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-
?
7,8-dihydroneopterin 3'-triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
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-
-
?
additional information
?
-
-
the sequence of reaction steps include redox transfer between atoms N5, C6 and C1' and unusual triphosphate elimination at the C2'-C3' bond in the side chain
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-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
23 bp exon 3 skipping in transcription rather than post-transcriptional mechanisms is a major cause of the low PTPS protein expression in human macrophages and related cell types. The exon lacking leads to a premature stop codon encoding for a shorter protein instead of the full-length functional enzyme
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?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
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rate-limiting enzyme in the synthesis of human tetrahydrobiopterin
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?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the first step in the conversion of 7,8-dihydroneopterin triphosphate to tetrahydrobiopterin
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme is involved in tetrahydrobiopterin biosynthesis
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme is post-translationally phosphorylated in several Ser residues by protein kinases. The enzyme requires the phosphoserine 19 residue for maximal activity under in vivo conditions. Mutant enzymes with alterations in the protein kinase recognition site, phosphoserine 19 residue, are not phosphorylated by protein kinase and have reduced activity
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?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme is involved in tetrahydrobiopterin biosynthesis
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme has six active sites located at the interface of three subunits. The enzyme contains an intersubunit catalytic triad motif composed of the amino acid residues Cys A42, His B89 and Asp B88 which is involved in the abstraction of protons from the substrate side-chain carbons. The gamma and beta phosphates of the substrate are essential for substrate binding and enhance the catalytic efficiency
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?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
one of the enzymes involved in tetrahydrobiopterin biosynthesis
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the second step of tetrahydrobiopterin (BH4) synthesis
-
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
