4.2.3.12: 6-pyruvoyltetrahydropterin synthase

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For detailed information about 6-pyruvoyltetrahydropterin synthase, go to the full flat file.

Word Map on EC 4.2.3.12

4.2.3.12

phosphatases

protein-tyrosine

phosphotyrosine

src

hyperphenylalaninemia

bh4

sepiapterin

orthovanadate

dual-specificity

cyclohydrolase

tcptp

dihydropteridine

vanadate

receptor-like

receptor-type

phenylarsine

rfviii

pterins

ptp-pest

ptp-1b

5-hydroxytryptophan

sulfenic

pteridines

ptpalpha

phosphotyrosyl

tyrosine-specific

thoracotomy

phenylketonuria

medicine

ptpro

gtpch

haemophilia

substrate-trapping

dystonia

pervanadate

non-receptor

csk

antigen-related

ptpn22

cdc25

Reaction

Synonyms

2-amino-4-oxo-6-(erythro-1',2',3'-trihydroxypropyl)-7,8-dihydroxypterdine triphosphate lyase, 6-(1,2-dioxopropyl)tetrahydropterin synthase, 6-carboxy-5,6,7,8-tetrahydropterin synthase, 6-pyruvoyl tetrahydrobiopterin synthase, 6-pyruvoyl-tetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase paralog, 6-pyruvoyltetrahydropterin synthase [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [25-glutamine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit), 6-pyruvoyltetrahydropterin synthase-like protein, EC 4.6.1.10, ePTPS, PH0634, PPH4 synthase, PPH4S, protein purple, PTP synthase, PTPS, PTPS homologue, PTPS-III, PTS, pyruvoyltetrahydropterin synthase, SCO 6650, synthase, 6-pyruvoyltetrahydropterin, synthase, 6-pyruvoyltetrahydropterin [16-cysteine] (human clone lamda HSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [25-glutamine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [87-leucine] (human clone lamdaHSY2 gene PCBD subunit), synthase, 6-pyruvoyltetrahydropterin [de-57-valine] (human clone lambdaHSY2 gene PCBD subunit)

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.12 6-pyruvoyltetrahydropterin synthase

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Results	in table
6	Activating Compound
1974	AA Sequence
2	Application
5	CAS Registry Number
21	Cloned(Commentary)
2	Cofactor
6	Crystallization (Commentary)
1116	Disease/ Diagnostics
1	General Stability
24	Inhibitors
34	KM Value [mM]
6	Localization
32	Metals/Ions
42	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
61	Organism
7	Pathway
32	PDB ID
18	pH Optimum
1	pH Range
4	Posttranslational Modification
26	Protein Variants
25	Purification (Commentary)
3	Reaction
4	Reaction Type
55	Reference
37	Source Tissue
40	Specific Activity [micromol/min/mg]
7	Storage Stability
69	Substrates and Products (Substrate)
40	Subunits
49	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
6	Turnover Number [1/s]

Cloned

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Cloned on EC 4.2.3.12 - 6-pyruvoyltetrahydropterin synthase

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cloned

Rattus norvegicus

P27213

648564

cloned in Escherichia coli

2 entries

expressed as maltose-binding-6-pyruvoyl-tetrahydropterin-synthase fusion protein

2 entries

expressed in Escherichia coli as a His-tagged fusion protein

2 entries

expressed in Escherichia coli BL21(DE3)

Escherichia coli

702280

expressed in Escherichia coli BL21(DE3) cells

Homo sapiens

Q03393

748379

expression in Cos-1 cells

Homo sapiens

664165

expression in Escherichia coli

4 entries

expression in Escherichia coli and COS-1 cells, wild-type enzyme and 4 naturally occurring mutants

Homo sapiens

648563

His-tagged version expressed in Escherichia coli BL21(DE3)

2 entries