4.2.3.118: 2-methylisoborneol synthase
This is an abbreviated version!
For detailed information about 2-methylisoborneol synthase, go to the full flat file.
Word Map on EC 4.2.3.118
Reaction
Synonyms
2-MIB cyclase, 2-MIB synthase, MIB synthase, MIBS, MIBSg, monoterpene cyclase, sco7700
ECTree
4.2.3.118 2-methylisoborneol synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.3.118 - 2-methylisoborneol synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
geranyl diphosphate + H2O
limonene + diphosphate
-
products are 6% alpha-pinene, 23% beta-pinene , 32% limonene, 29% gamma-terpinene, and 120% delta-terpinene
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
-
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
-
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
-
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
major reaction product
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
major reaction product
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
-
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
-
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
-
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
plus trace amounts of 2-methylbornene
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145
-
-
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
-
-
?
(E)-2-methylgeranyl diphosphate + H2O
2-methylisoborneol + diphosphate
-
-
-
?
2-fluorolinalyl diphosphate + H2O
(1R)-(+)-camphor + HF + diphosphate
-
single cyclic product, obtained via the (4R)-alpha-2-fluoroterpinyl carbocation intermediate. The initially generated 2-fluoroisoborneol cyclization product is unstable and undergoes elimination of hydrogen fluoride to yield (1R)-(+)-camphor
-
?
2-fluorolinalyl diphosphate + H2O
(1R)-(+)-camphor + HF + diphosphate
-
single cyclic product, obtained via the (4R)-alpha-2-fluoroterpinyl carbocation intermediate. The initially generated 2-fluoroisoborneol cyclization product is unstable and undergoes elimination of hydrogen fluoride to yield (1R)-(+)-camphor
-
?
2-methyllinalyl diphosphate + H2O
2-methylisoborneol + diphosphate
natural intermediate of the cyclization reaction
-
-
?
2-methyllinalyl diphosphate + H2O
2-methylisoborneol + diphosphate
natural intermediate of the cyclization reaction
-
-
?
2-methylneryl diphosphate + H2O
2-methyllimonene
Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145
-
-
-
?
additional information
?
-
GC-MS analysis for product identification and quantification
-
-
?
additional information
?
-
GC-MS analysis for product identification and quantification
-
-
?
additional information
?
-
cyclization of (E)-2-methylgeranyl diphosphate most likely occurs by a mechanism closely resembling that established for the conversion of geranyl diphosphate to bornyl diphosphate, except that the penultimate bornyl cation is quenched on the exo face by water, analogous to the formation of fenchol, rather than by internal return of the diphosphate to the endo face
-
-
?
additional information
?
-
-
cyclization of (E)-2-methylgeranyl diphosphate most likely occurs by a mechanism closely resembling that established for the conversion of geranyl diphosphate to bornyl diphosphate, except that the penultimate bornyl cation is quenched on the exo face by water, analogous to the formation of fenchol, rather than by internal return of the diphosphate to the endo face
-
-
?
additional information
?
-
no substrate: farnesyl diphosphate, geranylgeranyl diphosphate
-
-
?
additional information
?
-
-
no substrate: farnesyl diphosphate, geranylgeranyl diphosphate
-
-
?
