4.2.3.108: 1,8-cineole synthase
This is an abbreviated version!
For detailed information about 1,8-cineole synthase, go to the full flat file.
Word Map on EC 4.2.3.108
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4.2.3.108
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monoterpene
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synthases
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terpene
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salvia
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officinalis
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+-bornyl
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sabinene
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sage
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lamiaceae
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trichome
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eucalyptus
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camphor
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multi-product
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spasmolytic
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hoffmanns
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astringent
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lavandula
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caryophyllene
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linalyl
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beta-pinene
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gpp
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carbocation
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lavender
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hypoxylon
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terpinolene
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alpha-terpineole
- 4.2.3.108
-
monoterpene
- synthases
-
terpene
- salvia
- officinalis
-
+-bornyl
- sabinene
- sage
- lamiaceae
- trichome
- eucalyptus
- camphor
-
multi-product
-
spasmolytic
-
hoffmanns
-
astringent
- lavandula
- caryophyllene
-
linalyl
- beta-pinene
- gpp
-
carbocation
- lavender
- hypoxylon
- terpinolene
-
alpha-terpineole
Reaction
Synonyms
1,8-cineole cyclase, 1,8-cineole synthetase, AaTPS6, CIN, CinS, geranyl pyrophoshate:1,8-cineole cyclase, leucoplast 1,8-cineole synthase, LnTPS1, plastid terpineol synthase, SabS1, SCLAV_p0982, SSCG_00536, SSS, TER, TPS1, TPS6
ECTree
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Systematic Name
Systematic Name on EC 4.2.3.108 - 1,8-cineole synthase
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geranyl-diphosphate diphosphate-lyase (cyclizing, 1,8-cineole-forming)
Requires Mn2+ or Zn2+. Mg2+ is less effective than either. 1,8-Cineole is the main product from the enzyme with just traces of other monoterpenoids. The oxygen atom is derived from water. The reaction proceeds via linalyl diphosphate and alpha-terpineol, the stereochemistry of both depends on the organism. However neither intermediate can substitute for geranyl diphosphate. The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)-linalyl diphosphate [1-3] while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate [4].