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4.2.3.107: (+)-car-3-ene synthase

This is an abbreviated version!
For detailed information about (+)-car-3-ene synthase, go to the full flat file.

Word Map on EC 4.2.3.107

Reaction

geranyl diphosphate
=
(+)-car-3-ene
+
diphosphate

Synonyms

(+)-3-carene synthase, 3-carene cyclase, 3-carene synthase, 3CAR, 3CARS, JF67, Li3CARS, TPS-3car1, TPS-3car2, TPS-3car3

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.107 (+)-car-3-ene synthase

Substrates Products

Substrates Products on EC 4.2.3.107 - (+)-car-3-ene synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3R)-linalyl diphosphate
? + diphosphate
show the reaction diagram
-
-
the velocity of the reaction with the (3S)-linalyl enantiomer is 25fold greater than the velocity with the (3R)-enantiomer and twice that of the natural substrate, geranyl diphosphate. Cyclization of the linalyl intermediate is faster than the coupled isomerization and cyclization of the geranyl substrate
-
?
(3R)-linalyl diphosphate
myrcene + diphosphate
show the reaction diagram
-
-
-
-
?
(3S)-linalyl diphosphate
(+)-car-3-ene + diphosphate
show the reaction diagram
-
-
more than 99.9% optically pure
-
?
(3S)-linalyl diphosphate
? + diphosphate
show the reaction diagram
-
-
the velocity of the reaction with the (3S)-linalyl enantiomer is 25fold greater than the velocity with the (3R)-enantiomer and twice that of the natural substrate, geranyl diphosphate. Cyclization of the linalyl intermediate is faster than the coupled isomerization and cyclization of the geranyl substrate
-
?
geranyl diphosphate
(+)-car-3-ene + diphosphate
show the reaction diagram
neryl diphosphate
limonene + diphosphate
show the reaction diagram
low activity, neryl diphosphate is transformed into limonene (33%), alpha-terpinolene (29%) and alpha-thujene (20%) as main products, and minor amounts of a few other monoterpenes including 3-carene (8.5%)
-
-
?
additional information
?
-