4.2.3.107: (+)-car-3-ene synthase
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For detailed information about (+)-car-3-ene synthase, go to the full flat file.
Word Map on EC 4.2.3.107
Reaction
Synonyms
(+)-3-carene synthase, 3-carene cyclase, 3-carene synthase, 3CAR, 3CARS, JF67, Li3CARS, TPS-3car1, TPS-3car2, TPS-3car3
ECTree
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General Information on EC 4.2.3.107 - (+)-car-3-ene synthase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
evolutionary inference from Lavandula TPS genes, Li3CARS is highly homologous to the Lavandula angustifolia limonene synthase (LaLIMS), and is clustered with this gene under angiosperm mTPSs (TPS-b) subfamily
metabolism
biosynthesis of monoterpenes catalyzed by recombinant Li3CARS from geranyl diphosphate (GPP, derived from plastidial 2-C-methyl-D-erythritol-4-phosphate pathway) and neryl diphosphate (NPP)
physiological function
additional information
physiological function
(+)-3-carene is associated with resistance of Sitka spruce to white pine weevil, Pissodes strobi. Variation of the (+)-3-carene phenotype is controlled by copy number variation of TPS-3car genes, variation of gene and protein expression, and variation in catalytic efficiencies
physiological function
lavenders produce essential oils consisting mainly of monoterpenes, including the potent antimicrobial and insecticidal monoterpene 3-carene. Gene Li3CARS encodes a leaf-specific, methyl jasmonate (MeJA)-responsive monoterpene synthase from Lavandula x intermedia. The transcriptional activity of Li3CARS correlates with 3-carene production. enzyme Li3CARS may play a defensive role in lavenders
additional information
homology-based molecular modeling of Li3CARS using the crystal structure of Salvia officinalis bornyl pyrophosphate synthase (SoBPPS) (PDB ID 1N1Z), containing the substrate analogue diphosphate (POP), as template
additional information
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homology-based molecular modeling of Li3CARS using the crystal structure of Salvia officinalis bornyl pyrophosphate synthase (SoBPPS) (PDB ID 1N1Z), containing the substrate analogue diphosphate (POP), as template
