4.2.2.B6: muropeptide lyase

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For detailed information about muropeptide lyase, go to the full flat file.

Reaction

GlcNAc-beta-(1->4)-Mur2Acoyl-L-Ala-gamma-D-Glu

1,6-anhydro-N-acetylmuramoyl-L-Ala-gamma-D-Glu

Synonyms

endolytic peptidoglycan lytic transglycosylase, GlcNAc-beta-(1->4)-Mur2Acoyl-L-Ala-gamma-D-Glu lyase (1,6-anhydromuramoyl-residue forming), MltE, muropeptide lyase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.2 Acting on polysaccharides

4.2.2.B6 muropeptide lyase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
2	Crystallization (Commentary)
1	General Information
3	Localization
3	Organism
1	Protein Variants
2	Purification (Commentary)
1	Reaction
3	Reference
4	Substrates and Products (Substrate)
1	Subunits
9	Synonyms

General Information

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General Information on EC 4.2.2.B6 - muropeptide lyase

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physiological function

Salmonella enterica subsp. enterica serovar Typhimurium

lytic transglycosylases, MltE and MltC, in combination increase transcriptional regulator CsgD expression and distinct colony morphotype on Congo red agar plates, named rdar. MltE and MltC work redundantly to regulate transcriptional regulator CsgD at the transcriptional and posttranscriptional levels. The effect of MltE and MltC on CsgD levels is independent of the known regulatory pathways that sense cell envelope stress. The mltE deletion mutant does not show a change in rdar morphotype expression. The overexpression of MltE from a plasmid leads to an upregulated rdar morphotype after 17 h, and upon extended incubation it manifests as an extended matrix structure on Congo red agar plates

729918