4.2.2.7: heparin lyase

This is an abbreviated version!
For detailed information about heparin lyase, go to the full flat file.

Word Map on EC 4.2.2.7

4.2.2.7

heparan

proteoglycans

glycosaminoglycans

chondroitinase

endothelial

chondroitin

oligosaccharide

disaccharide

anticoagulant

coagulation

flavobacterium

heparin-like

heparin-binding

antithrombin

dermatan

heparinum

protamine

clot

depolymerization

hyaluronic

hspgs

hyaluronidase

chlorate

lyases

n-sulfated

thromboplastin

glycocalyx

heparanase

iduronic

tetrasaccharide

thromboelastography

teg

atiii

anti-xa

6-o-sulfate

heparin-derived

o-sulfation

decasaccharide

analysis

thromboelastometry

lmwhs

heptose

enoxaparin

syndecan-4

tinzaparin

medicine

trisulfated

synthesis

heparinoids

kaolin

octasaccharide

polybrene

beta-vldl

Reaction

Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends =

Synonyms

Hep III, HepA, heparin degrading enzyme, Heparin eliminase, heparin lyase, heparin lyase 1, heparin lyase I, heparin lyase II, Heparinase, heparinase I, heparinase II, heparitinase II, heparitinase III, HepI, HepII, HepP, HMPREF1016_02668, Lyase, heparin, PA14_23430, Pedsa_1818, PL12a

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.2 Acting on polysaccharides

4.2.2.7 heparin lyase

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Results	in table
8	Activating Compound
88	AA Sequence
9	Application
2	CAS Registry Number
14	Cloned(Commentary)
4	Crystallization (Commentary)
285	Disease/ Diagnostics
4	Expression
8	General Information
3	General Stability
41	Inhibitors
8	kcat/KM [mM/s]
1	Ki Value [mM]
44	KM Value [mM]
8	Localization
44	Metals/Ions
16	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
75	Organism
1	Pathway
5	PDB ID
20	pH Optimum
8	pH Range
4	pH Stability
4	pI Value
42	Protein Variants
27	Purification (Commentary)
1	Reaction
4	Reaction Type
64	Reference
7	Source Tissue
18	Specific Activity [micromol/min/mg]
8	Storage Stability
102	Substrates and Products (Substrate)
19	Subunits
58	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
6	Temperature Range [°C]
13	Temperature Stability [°C]
8	Turnover Number [1/s]

pH Stability

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pH Stability on EC 4.2.2.7 - heparin lyase

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6 - 9

Pseudopedobacter saltans

F0S8P2

stable for 1 h

746759

Pedobacter heparinus

stability maximum

5972, 5982

7 - 11

Pedobacter heparinus

0°C, 30 min, stable. Inactivated out of this range

681056