4.2.2.7: heparin lyase
This is an abbreviated version!
For detailed information about heparin lyase, go to the full flat file.
Word Map on EC 4.2.2.7
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4.2.2.7
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heparan
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proteoglycans
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glycosaminoglycans
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chondroitinase
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endothelial
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chondroitin
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oligosaccharide
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disaccharide
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anticoagulant
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coagulation
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flavobacterium
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heparin-like
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heparin-binding
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antithrombin
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dermatan
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heparinum
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protamine
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clot
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depolymerization
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hyaluronic
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hspgs
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hyaluronidase
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chlorate
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lyases
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n-sulfated
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thromboplastin
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glycocalyx
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heparanase
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iduronic
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tetrasaccharide
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thromboelastography
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teg
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atiii
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anti-xa
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6-o-sulfate
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heparin-derived
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o-sulfation
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decasaccharide
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analysis
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thromboelastometry
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lmwhs
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heptose
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enoxaparin
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syndecan-4
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tinzaparin
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medicine
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trisulfated
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synthesis
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heparinoids
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kaolin
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octasaccharide
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polybrene
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beta-vldl
- 4.2.2.7
- heparan
- proteoglycans
- glycosaminoglycans
- chondroitinase
- endothelial
- chondroitin
- oligosaccharide
- disaccharide
-
anticoagulant
-
coagulation
- flavobacterium
-
heparin-like
-
heparin-binding
- antithrombin
- dermatan
- heparinum
- protamine
- clot
-
depolymerization
-
hyaluronic
-
hspgs
- hyaluronidase
- chlorate
- lyases
-
n-sulfated
- thromboplastin
-
glycocalyx
- heparanase
-
iduronic
- tetrasaccharide
-
thromboelastography
- teg
-
atiii
-
anti-xa
-
6-o-sulfate
-
heparin-derived
-
o-sulfation
- decasaccharide
- analysis
-
thromboelastometry
- lmwhs
-
heptose
- enoxaparin
- syndecan-4
- tinzaparin
- medicine
-
trisulfated
- synthesis
-
heparinoids
- kaolin
- octasaccharide
- polybrene
-
beta-vldl
Reaction
Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends =
Synonyms
Hep III, HepA, heparin degrading enzyme, Heparin eliminase, heparin lyase, heparin lyase 1, heparin lyase I, heparin lyase II, Heparinase, heparinase I, heparinase II, heparitinase II, heparitinase III, HepI, HepII, HepP, HMPREF1016_02668, Lyase, heparin, PA14_23430, Pedsa_1818, PL12a
ECTree
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KM Value
KM Value on EC 4.2.2.7 - heparin lyase
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0.018
heparin pentasaccharide
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cleavage of a synthetic pentasaccharide containing an antithrombin III binding site into a trisaccharide and a disaccharide, pH 7.0, 30ºC
additional information
heparin
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several double and triple mutants of the calcium-coordinating residues
additional information
heparin
kcat/Km value 19.3 ml/mg/s, pH 6.0, 50°C