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4.2.2.7: heparin lyase

This is an abbreviated version!
For detailed information about heparin lyase, go to the full flat file.

Word Map on EC 4.2.2.7

Reaction

Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends =

Synonyms

Hep III, HepA, heparin degrading enzyme, Heparin eliminase, heparin lyase, heparin lyase 1, heparin lyase I, heparin lyase II, Heparinase, heparinase I, heparinase II, heparitinase II, heparitinase III, HepI, HepII, HepP, HMPREF1016_02668, Lyase, heparin, PA14_23430, Pedsa_1818, PL12a

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.2 Acting on polysaccharides
                4.2.2.7 heparin lyase

KM Value

KM Value on EC 4.2.2.7 - heparin lyase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0036 - 0.21
heparan sulfate
0.0023 - 1.2
heparin
0.018
heparin pentasaccharide
-
cleavage of a synthetic pentasaccharide containing an antithrombin III binding site into a trisaccharide and a disaccharide, pH 7.0, 30ºC
0.0046 - 0.2395
heparin, 20-mer
-
0.0541 - 5.015
heparin, 6-mer
-
0.0182
heparin, 8-mer
-
wild-type protein
-
0.042
N-acetyl-de-O-sulfated heparin
-
pH 7.4, 37ºC
-
additional information
acharan sulfate
-