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4.2.2.7: heparin lyase

This is an abbreviated version!
For detailed information about heparin lyase, go to the full flat file.

Word Map on EC 4.2.2.7

Reaction

Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends =

Synonyms

Hep III, HepA, heparin degrading enzyme, Heparin eliminase, heparin lyase, heparin lyase 1, heparin lyase I, heparin lyase II, Heparinase, heparinase I, heparinase II, heparitinase II, heparitinase III, HepI, HepII, HepP, HMPREF1016_02668, Lyase, heparin, PA14_23430, Pedsa_1818, PL12a

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.2 Acting on polysaccharides
                4.2.2.7 heparin lyase

Inhibitors

Inhibitors on EC 4.2.2.7 - heparin lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
carbodiimide
-
0.1 mM, 27% inhibition
diethyl dicarbonate
-
-
Fe3+
-
-
heparin with reduced carboxylate group
-
competitive inhibitor
-
iodoacetic acid
-
-
Mn2+
1 mM, about 30% inhibition
Morus alba extract
-
-
-
N-Acetylimidazole
-
80% inhibition at 1 mM concentration of inhibitor, indicates the necessity of tyrosine residues in the active site
N-bromosuccinimide
-
30% inhibition at 1 mM concentration of inhibitor
N-tosyl-L-lysine-chloromethyl ketone
-
0.1 mM, 84% inhibition
Na+-heparin
-
-
-
p-chloromercuriphenyl sulfonic acid
Polyvinyl sulfate
-
-
resveratrol
-
-
SO42-
-
slight
additional information
-
specific desulfation of the alpha-L-iduronic acid, 2-O-sulfate ring or the desulfation of the acid alpha-L-iduronic, 2-O-sulfate ring, followed by epimerization of its iduronic to galacturonic acid abolishes its degradation by heparinase I, as well as leading to the formation of competitive inhibitors
-