4.2.2.7: heparin lyase
This is an abbreviated version!
For detailed information about heparin lyase, go to the full flat file.
Word Map on EC 4.2.2.7
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4.2.2.7
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heparan
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proteoglycans
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glycosaminoglycans
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chondroitinase
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endothelial
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chondroitin
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oligosaccharide
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disaccharide
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anticoagulant
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coagulation
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flavobacterium
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heparin-like
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heparin-binding
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antithrombin
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dermatan
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heparinum
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protamine
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clot
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depolymerization
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hyaluronic
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hspgs
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hyaluronidase
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chlorate
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lyases
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n-sulfated
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thromboplastin
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glycocalyx
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heparanase
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iduronic
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tetrasaccharide
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thromboelastography
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teg
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atiii
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anti-xa
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6-o-sulfate
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heparin-derived
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o-sulfation
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decasaccharide
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analysis
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thromboelastometry
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lmwhs
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heptose
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enoxaparin
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syndecan-4
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tinzaparin
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medicine
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trisulfated
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synthesis
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heparinoids
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kaolin
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octasaccharide
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polybrene
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beta-vldl
- 4.2.2.7
- heparan
- proteoglycans
- glycosaminoglycans
- chondroitinase
- endothelial
- chondroitin
- oligosaccharide
- disaccharide
-
anticoagulant
-
coagulation
- flavobacterium
-
heparin-like
-
heparin-binding
- antithrombin
- dermatan
- heparinum
- protamine
- clot
-
depolymerization
-
hyaluronic
-
hspgs
- hyaluronidase
- chlorate
- lyases
-
n-sulfated
- thromboplastin
-
glycocalyx
- heparanase
-
iduronic
- tetrasaccharide
-
thromboelastography
- teg
-
atiii
-
anti-xa
-
6-o-sulfate
-
heparin-derived
-
o-sulfation
- decasaccharide
- analysis
-
thromboelastometry
- lmwhs
-
heptose
- enoxaparin
- syndecan-4
- tinzaparin
- medicine
-
trisulfated
- synthesis
-
heparinoids
- kaolin
- octasaccharide
- polybrene
-
beta-vldl
Reaction
Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends =
Synonyms
Hep III, HepA, heparin degrading enzyme, Heparin eliminase, heparin lyase, heparin lyase 1, heparin lyase I, heparin lyase II, Heparinase, heparinase I, heparinase II, heparitinase II, heparitinase III, HepI, HepII, HepP, HMPREF1016_02668, Lyase, heparin, PA14_23430, Pedsa_1818, PL12a
ECTree
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Inhibitors
Inhibitors on EC 4.2.2.7 - heparin lyase
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N-Acetylimidazole
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80% inhibition at 1 mM concentration of inhibitor, indicates the necessity of tyrosine residues in the active site
additional information
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specific desulfation of the alpha-L-iduronic acid, 2-O-sulfate ring or the desulfation of the acid alpha-L-iduronic, 2-O-sulfate ring, followed by epimerization of its iduronic to galacturonic acid abolishes its degradation by heparinase I, as well as leading to the formation of competitive inhibitors
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1 mM EDTA completely inactivates heparinase I in the presence of 2 mM Ca2+. Inhibition is reversible, the reintroduction of calcium ions into the system completely restores the enzymatic activity of heparinase I