4.2.2.5: chondroitin AC lyase

This is an abbreviated version!
For detailed information about chondroitin AC lyase, go to the full flat file.

Word Map on EC 4.2.2.5

4.2.2.5

glycosaminoglycans

proteoglycans

dermatan

heparan

hyaluronic

hyaluronidase

glucuronic

heparinum

flavobacterium

heparitinase

6-sulfate

lyases

iduronic

4-sulphate

glca

cetylpyridinium

hexasaccharide

monosulfated

cuprolinic

3hglucosamine

galactosaminoglycans

aurescens

undersulfated

oversulfated

keratanase

35ssulfate

analysis

medicine

synthesis

trisulfated

blue-positive

chondroitin-4-sulfate

food industry

cupromeronic

Reaction

[1,3-beta-D-glucuronic acid-1,4-beta-D-hexosylamine]n

= n-1 4-deoxy-beta-D-gluc-4-enuronosyl-1,4-beta-D-hexosylamine +

[1,3-beta-D-glucuronic acid-1,4-beta-D-hexosylamine]

Synonyms

A-Chase, AC I lyase, c-ACI, c-ACII, ChnAC, chon-AC-lyase, ChonAC, chondroitin AC eliminase, chondroitin AC I lyase, Chondroitin AC lyase, chondroitin ACII lyase, chondroitin lyase AC, chondroitin sulfate lyase, chondroitinase, chondroitinase AC, chondroitinase ACI, chondroitinase ACII, ChSase-AC, EC 4.2.99.6, F-Chase, lyase, chondroitin AC, Pedsa_3808, PL8A

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.2 Acting on polysaccharides

4.2.2.5 chondroitin AC lyase

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Results	in table
4	Activating Compound
144	AA Sequence
5	Application
1	CAS Registry Number
9	Cloned(Commentary)
6	Crystallization (Commentary)
33	Disease/ Diagnostics
1	General Information
71	Inhibitors
5	Ki Value [mM]
51	KM Value [mM]
7	Localization
11	Metals/Ions
13	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
58	Organism
3	Pathway
11	PDB ID
13	pH Optimum
2	pH Range
2	pH Stability
2	pI Value
5	Posttranslational Modification
19	Protein Variants
12	Purification (Commentary)
14	Reaction
2	Reaction Type
53	Reference
3	Source Tissue
33	Specific Activity [micromol/min/mg]
1	Storage Stability
130	Substrates and Products (Substrate)
12	Subunits
40	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
4	Temperature Range [°C]
7	Temperature Stability [°C]
26	Turnover Number [1/s]

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0.041

4-O-(2',4'-dinitrophenyl)-beta-D-glucopyranosiruronic acid

Pedobacter heparinus

pH 6.8, 30°C, wild-type enzyme

664604

0.16

benzyl 4-deoxy-4-fluoro-beta-D-glucopyranosiduronic acid

2 entries

0.019

benzyl 4-O-(2',4'-dinitrophenyl)-beta-D-glucopyranosiduronic acid

Pedobacter heparinus

pH 6.8

649318, 651587

0.027

benzyl 4-O-(2'-nitrophenyl)-beta-D-glucopyranosiduronic acid

Pedobacter heparinus

pH 6.8

651587

0.019

benzyl 4-O-(3',4'-dinitrophenyl)-beta-D-glucopyranosiduronic acid

Pedobacter heparinus

pH 6.8

651587

0.035

benzyl 4-O-(4'-chloro-2'-nitrophenyl)-beta-D-glucopyranosiduronic acid

Pedobacter heparinus

pH 6.8

651587

0.005

benzyl S-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-(1-4)-4-deoxy-4-thio-beta-D-glucopyranosiduronic acid

Pedobacter heparinus

664524

840 - 868

chondroitin

2 entries

234 - 403

chondroitin 4-sulfate

3 entries

345 - 855

chondroitin 6-sulfate

4 entries

570 - 1200

hyaluronate

2 entries

2.3

phenyl 4-deoxy-4-fluoro-beta-D-glucopyranosiduronic acid

2 entries

0.0015 - 0.0016

phenyl 4-methylumbelliferyl-beta-D-glucopyranosiduronic acid

2 entries

additional information

2 entries