4.2.2.3: mannuronate-specific alginate lyase

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For detailed information about mannuronate-specific alginate lyase, go to the full flat file.

Reaction

Synonyms

(poly alpha-l-guluronate) lyase, A1 alginate lyase, A1-II, A1-III, A1-IV', A1m, A1mU, A9mC, A9mL, A9mT, AAlyase, AkAly30, AL2, alg, ALG-5, Alg-A, Alg17C, Alg2A, Alg7D, AlgA, AlgB, AlgE7, AlgI, alginase I, alginate lyase, alginate lyase A, alginate lyase A1-II, alginate lyase A1-II', alginate lyase A1-III, alginate lyase AlyPEEC, alginate lyase Atu3025, alginate lyase B, alginate lyase C, alginate lyase I, alginate lyase VI, alginate lyase1-III, AlgL, ALY, ALY-1, Aly-SJ02, Aly1, Aly2, Aly28, Aly30, Aly32, Aly33, Aly35, Aly7B, AlyA, AlyA1, AlyA2, AlyA3, AlyA5, AlyB, AlyDW11, ALYIII, alyPEEC, AlyPI, AlyPM, AlyQ, AlyV5, AlyVI, Atu3025, AXE80_11190, CL2, EC 4.2.99.4, endo-type alginate lyase, endolytic poly(M) lyase, endolytic polymannuronate lyase, exotype alginate lyase, HdAlex, hdalex-1, HdAly, KJ-2 alginate lyase, LbAly28, lyase AlyA, lyase, alginate, Lysis protein, M block-specific polymannuronate lyase, mannuronate alginate lyase, MJ-3 alginate lyase, More, MY04_2544, NIS_0185, Oal17A, oligoalginate lyase, PL-5 alginate lyase, PM lyase, poly(1,4-beta-D-mannuronide) lyase, poly(beta-D-1,4-mannuronide) lyase, Poly(beta-D-mannuronate) lyase, poly(M) lyase, poly(M)lyase, Poly(mana) alginate lyase, poly(mana)alginate lyase, polymannuronate lyase, polyMG-specific alginate lyase, protein PA1167, SP2, V12B01_24254, V12B01_24259, WP_053404615

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.2 Acting on polysaccharides

                4.2.2.3 mannuronate-specific alginate lyase

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Results	in table
53	Activating Compound
1671	AA Sequence
86	Application
2	CAS Registry Number
78	Cloned(Commentary)
16	Crystallization (Commentary)
48	Disease/ Diagnostics
1	Expression
33	General Information
3	General Stability
187	Inhibitors
20	kcat/KM [mM/s]
1	Ki Value [mM]
72	KM Value [mM]
77	Localization
213	Metals/Ions
128	Molecular Weight [Da]
138	Natural Substrates/ Products (Substrates)
298	Organism
3	Pathway
41	PDB ID
128	pH Optimum
35	pH Range
29	pH Stability
35	pI Value
8	Posttranslational Modification
164	Protein Variants
89	Purification (Commentary)
61	Reaction
1	Reaction Type
237	Reference
1	Renatured (Commentary)
44	Source Tissue
115	Specific Activity [micromol/min/mg]
6	Storage Stability
574	Substrates and Products (Substrate)
95	Subunits
308	Synonyms
1	Systematic Name
90	Temperature Optimum [°C]
28	Temperature Range [°C]
69	Temperature Stability [°C]
36	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.2.3 - mannuronate-specific alginate lyase

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SYSTEMATIC NAME

IUBMB Comments

alginate beta-D-mannuronate-uronate lyase

The enzyme catalyses the degradation of alginate by a beta-elimination reaction. It cleaves the (1->4) bond between beta-D-mannuronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to four residues, with preference for shorter products. cf. EC 4.2.2.11, guluronate-specific alginate lyase.