4.2.2.21: chondroitin-sulfate-ABC exolyase

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For detailed information about chondroitin-sulfate-ABC exolyase, go to the full flat file.

Reaction

Synonyms

BactnABC, cABCII, chABC, Chondroitin Sulfate Lyase ABC, chondroitinase ABC, chondroitinase ABC II, chondroitinase AC, chondroitinase ACII, chondroitinase-ABC, ChS ABC lyase II, EC 4.2.2.4, EC 4.2.99.6, HCLase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.2 Acting on polysaccharides

                4.2.2.21 chondroitin-sulfate-ABC exolyase

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Results	in table
3	Activating Compound
20	AA Sequence
9	Application
4	Cloned(Commentary)
1	Crystallization (Commentary)
2	General Stability
16	Inhibitors
7	kcat/KM [mM/s]
56	KM Value [mM]
1	Localization
8	Metals/Ions
11	Molecular Weight [Da]
31	Organism
4	Pathway
2	PDB ID
17	pH Optimum
2	pH Range
5	pI Value
45	Protein Variants
8	Purification (Commentary)
3	Reaction
28	Reference
1	Source Tissue
21	Specific Activity [micromol/min/mg]
2	Storage Stability
88	Substrates and Products (Substrate)
7	Subunits
22	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
55	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.2.21 - chondroitin-sulfate-ABC exolyase

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SYSTEMATIC NAME

IUBMB Comments

chondroitin-sulfate-ABC exolyase

This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. The related enzyme EC 4.2.2.20, chondroitin-sulfate-ABC endolyase, has the same substrate specificity but produces a mixture of oligosaccharides of different sizes that are ultimately degraded to tetra- and disaccharides [4]. Both enzymes act by the removal of a relatively acidic C-5 proton of the uronic acid followed by the elimination of a 4-linked hexosamine, resulting in the formation of an unsaturated C4---C5 bond on the hexuronic acid moiety of the products [4,6].