Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.2.2.21: chondroitin-sulfate-ABC exolyase

This is an abbreviated version!
For detailed information about chondroitin-sulfate-ABC exolyase, go to the full flat file.

Word Map on EC 4.2.2.21

Reaction

[GlcAbeta(1-3)GalNAc(4S)beta(1-4)]3
=
[GlcAbeta(1-3)GalNAc(4S)beta(1-4)]2
+
2-(acetylamino)-2-deoxy-3-O-alpha-L-threo-hex-4-enopyranuronosyl-4-O-sulfo-beta-D-galactopyranose

Synonyms

BactnABC, cABCII, chABC, Chondroitin Sulfate Lyase ABC, chondroitinase ABC, chondroitinase ABC II, chondroitinase AC, chondroitinase ACII, chondroitinase-ABC, ChS ABC lyase II, EC 4.2.2.4, EC 4.2.99.6, HCLase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.2 Acting on polysaccharides
                4.2.2.21 chondroitin-sulfate-ABC exolyase

Reference

Reference on EC 4.2.2.21 - chondroitin-sulfate-ABC exolyase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hascall, V.C.; Riolo, R.L.; Hayward, J.; Reynolds, C.C.
Treatment of bovine nasal cartilage proteoglycan with chondroitinases from Flavobacterium heparinum and Proteus vulgaris
J. Biol. Chem.
247
4521-4528
1972
Pedobacter heparinus, Proteus vulgaris
Manually annotated by BRENDA team
Michelacci, Y.M.; Horton, D.S.P.Q.; Poblacion, C.A.
Isolation and characterization of an induced chondroitinase ABC from Flavobacterium heparinum
Biochim. Biophys. Acta
923
291-301
1987
Pedobacter heparinus
Manually annotated by BRENDA team
Sato, N.; Murata, K.; Kimura, A.
Cultural conditions for the induction of chondroitinase ABC in Proteus vulgaris cells
J. Ferment. Technol.
64
155-159
1986
Proteus vulgaris
-
Manually annotated by BRENDA team
Sato, N.; Murata, K.; Kimura, A.
Subunit structure of chondroitinase ABC from Proteus vulgaris
Agric. Biol. Chem.
50
1057-1059
1986
Proteus vulgaris
-
Manually annotated by BRENDA team
Yamagata, T.; Saito, H.; Habuchi, O.; Suzuki, S.
Purification and properties of bacterial chondroitinases and chondrosulfatases
J. Biol. Chem.
243
1523-1535
1968
Pedobacter heparinus, Proteus vulgaris, Proteus vulgaris NCTC 4636
Manually annotated by BRENDA team
Linn, S.; Chan, T.; Lipeski, L.; Salyers, A.A.
Isolation and characterization of two chondroitin lyases from Bacteroides thetaiotaomicron
J. Bacteriol.
156
859-866
1983
Bacteroides thetaiotaomicron
Manually annotated by BRENDA team
Aguiarand, J.A.K.; Michelacci, Y.M.
Preparation and purification of Flavobacterium heparinum chondroitinases AC and B by hydrophobic interaction chromatography
Braz. J. Med. Biol. Res.
32
545-550
1999
Pedobacter heparinus
Manually annotated by BRENDA team
Takagaki, K.; Munakata, H.; Majima, M.; Kakizaki, I.; Endo, M.
Chimeric glycosaminoglycan oligosaccharides synthesized by enzymatic reconstruction and their use in substrate specificity determination of Streptococcus hyaluronidase
J. Biochem.
127
695-702
2000
Streptococcus dysgalactiae
Manually annotated by BRENDA team
Hamai, A.; Hashimoto, N.; Mochizuki, H.; Kato, F.; Makiguchi, Y.; Horie, K.; Suzuki, S.
Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides
J. Biol. Chem.
272
9123-9130
1997
Proteus vulgaris
Manually annotated by BRENDA team
Prabhakar, V.; Capila, I.; Bosques, C.J.; Pojasek, K.; Sasisekharan, R.
Chondroitinase ABC I from Proteus vulgaris: cloning, recombinant expression and active site identification
Biochem. J.
386
103-112
2005
Proteus vulgaris
Manually annotated by BRENDA team
Prabhakar, V.; Raman, R.; Capila, I.; Bosques, C.J.; Pojasek, K.; Sasisekharan, R.
Biochemical characterization of the chondroitinase ABC I active site
Biochem. J.
390
395-405
2005
Proteus vulgaris
Manually annotated by BRENDA team
Saito, H.; Yamagata, T.; Suzuki, S.
Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates
J. Biol. Chem.
243
1536-1542
1968
Pedobacter heparinus, Proteus vulgaris, Proteus vulgaris NCTC 4636
Manually annotated by BRENDA team
Suzuki, S.; Saito, H.; Yamagata, T.; Anno, K.; Seno, N.; Kawai, Y.; Furuhashi, T.
Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion
J. Biol. Chem.
243
1543-1550
1968
Proteus vulgaris
Manually annotated by BRENDA team
Zhang, Z.; Park, Y.; Kemp, M.M.; Zhao, W.; Im, A.R.; Shaya, D.; Cygler, M.; Kim, Y.S.; Linhardt, R.J.
Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern
Anal. Biochem.
385
57-64
2009
Paenarthrobacter aurescens, Bacteroides thetaiotaomicron (Q8A2I1)
Manually annotated by BRENDA team
Shaya, D.; Hahn, B.; Park, N.Y.; Sim, J.; Kim, Y.S.; Cygler, M.
Characterization of Chondroitin Sulfate Lyase ABC from Bacteroides thetaiotaomicron WAL2926
Biochemistry
47
6650-6661
2008
Bacteroides thetaiotaomicron (Q8A2I1), Bacteroides thetaiotaomicron
Manually annotated by BRENDA team
Shaya, D.; Hahn, B.; Bjerkan, T.M.; Kim, W.S.; Park, N.Y.; Sim, J.; Kim, Y.; Cygler, M.
Composite active site of chondroitin lyase ABC accepting both epimers of uronic acid
Glycobiology
18
270-277
2008
Bacteroides thetaiotaomicron (Q8A2I1)
Manually annotated by BRENDA team
Prabhakar, V.; Capila, I.; Soundararajan, V.; Raman, R.; Sasisekharan, R.
Recombinant expression, purification, and biochemical characterization of chondroitinase ABC II from Proteus vulgaris
J. Biol. Chem.
284
974-982
2009
Proteus vulgaris
Manually annotated by BRENDA team
Huang, W.C.; Kuo, W.C.; Hsu, S.H.; Cheng, C.H.; Liu, J.C.; Cheng, H.
Gait analysis of spinal cord injured rats after delivery of chondroitinase ABC and adult olfactory mucosa progenitor cell transplantation
Neurosci. Lett.
472
79-84
2010
Proteus vulgaris
Manually annotated by BRENDA team
Nakamae, T.; Tanaka, N.; Nakanishi, K.; Kamei, N.; Sasaki, H.; Hamasaki, T.; Yamada, K.; Yamamoto, R.; Izumi, B.; Ochi, M.
The effects of combining chondroitinase ABC and NEP1-40 on the corticospinal axon growth in organotypic co-cultures
Neurosci. Lett.
476
14-17
2010
Proteus vulgaris
Manually annotated by BRENDA team
Lee, H.; McKeon, R.J.; Bellamkonda, R.V.
Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury
Proc. Natl. Acad. Sci. USA
107
3340-3345
2010
Proteus vulgaris
Manually annotated by BRENDA team
Huang, Y.; Hsu, S.; Chen, M.; Hsieh, C.; Kuo, W.; Cheng, H.; Huang, Y.
Controlled release of chondroitinase ABC in chitosan-based scaffolds and PDLLA microspheres
Carbohydr. Polym.
84
788-793
2011
Proteus vulgaris
Manually annotated by BRENDA team
Wang, W.; Cai, X.; Han, N.; Han, W.; Sugahara, K.; Li, F.
Sequencing of chondroitin sulfate oligosaccharides using a novel exolyase from a marine bacterium that degrades hyaluronan and chondroitin sulfate/dermatan sulfate
Biochem. J.
474
3831-3848
2017
Vibrio sp. FC509 (A0A077ERI8)
Manually annotated by BRENDA team