4.2.2.21: chondroitin-sulfate-ABC exolyase
This is an abbreviated version!
For detailed information about chondroitin-sulfate-ABC exolyase, go to the full flat file.
Word Map on EC 4.2.2.21
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4.2.2.21
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glycosaminoglycans
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articular
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dermatan
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tensile
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4-sulfated
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chabc
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neocartilage
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fibrocartilage
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perineuronal
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chondroitinase-ac
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oversulfated
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l-iduronic
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neurocan
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analysis
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medicine
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galactosaminoglycans
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chondroitin-4-sulfate
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synthesis
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biotechnology
- 4.2.2.21
- glycosaminoglycans
-
articular
- dermatan
-
tensile
-
4-sulfated
- chabc
-
neocartilage
-
fibrocartilage
-
perineuronal
-
chondroitinase-ac
-
oversulfated
-
l-iduronic
- neurocan
- analysis
- medicine
- galactosaminoglycans
- chondroitin-4-sulfate
- synthesis
- biotechnology
Reaction
Synonyms
BactnABC, cABCII, chABC, Chondroitin Sulfate Lyase ABC, chondroitinase ABC, chondroitinase ABC II, chondroitinase AC, chondroitinase ACII, chondroitinase-ABC, ChS ABC lyase II, EC 4.2.2.4, EC 4.2.99.6, HCLase
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Metals Ions
Metals Ions on EC 4.2.2.21 - chondroitin-sulfate-ABC exolyase
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Ca2+
Mg2+
additional information
addition of Mg2+ or Ca2+ has a dramatically different effect on activity toward CS (glucuronic acid) and DS (iduronic acid). The specific activity for CS substrates increases only moderately (2fold) while an increase of 25fold is observed for DS
Ca2+
stimulates activity, particularly against dermatan sulfate
addition of Mg2+ or Ca2+ has a dramatically different effect on activity toward CS (glucuronic acid) and DS (iduronic acid). The specific activity for CS substrates increases only moderately (2fold) while an increase of 25fold is observed for DS
Mg2+
stimulates activity, particularly against dermatan sulfate
for the monovalent ions tested, increasing the concentration of Na+, K+, or CS+ chloride from 0 to 0.1 M increases the activity against all substrates. Further increases in salt concentration reduces the activity dramatically, with 50% inhibition occurring at 0.15 M and a nearly complete inhibition at 0.4 M salt
additional information
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for the monovalent ions tested, increasing the concentration of Na+, K+, or CS+ chloride from 0 to 0.1 M increases the activity against all substrates. Further increases in salt concentration reduces the activity dramatically, with 50% inhibition occurring at 0.15 M and a nearly complete inhibition at 0.4 M salt