4.2.2.21: chondroitin-sulfate-ABC exolyase
This is an abbreviated version!
For detailed information about chondroitin-sulfate-ABC exolyase, go to the full flat file.
Word Map on EC 4.2.2.21
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4.2.2.21
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glycosaminoglycans
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articular
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dermatan
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tensile
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4-sulfated
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chabc
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neocartilage
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fibrocartilage
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perineuronal
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chondroitinase-ac
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oversulfated
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l-iduronic
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neurocan
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analysis
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medicine
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galactosaminoglycans
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chondroitin-4-sulfate
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synthesis
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biotechnology
- 4.2.2.21
- glycosaminoglycans
-
articular
- dermatan
-
tensile
-
4-sulfated
- chabc
-
neocartilage
-
fibrocartilage
-
perineuronal
-
chondroitinase-ac
-
oversulfated
-
l-iduronic
- neurocan
- analysis
- medicine
- galactosaminoglycans
- chondroitin-4-sulfate
- synthesis
- biotechnology
Reaction
Synonyms
BactnABC, cABCII, chABC, Chondroitin Sulfate Lyase ABC, chondroitinase ABC, chondroitinase ABC II, chondroitinase AC, chondroitinase ACII, chondroitinase-ABC, ChS ABC lyase II, EC 4.2.2.4, EC 4.2.99.6, HCLase
ECTree
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Crystallization
Crystallization on EC 4.2.2.21 - chondroitin-sulfate-ABC exolyase
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crystal structure identifies additional structurally conserved residues potentially involved in catalysis. A conserved cluster located 12 A from the catalytic tetrad is shown. A His in this cluster is essential for catalysis of dermatane sulfate but not chondroitin sulfate. The enzyme utilizes a single substrate-binding site while having two partially overlapping active sites catalyzing the respective reactions. The spatial separation of the two sets of residues suggests a substrate-induced conformational change that brings all catalytically essential residues close together