Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

4.2.2.20: chondroitin-sulfate-ABC endolyase

This is an abbreviated version!
For detailed information about chondroitin-sulfate-ABC endolyase, go to the full flat file.

Word Map on EC 4.2.2.20

Reaction

R1-[beta-D-GalNAc-1,4-L-iduronic acid]-R2
=
R1-[beta-D-GalNAc]
 +
[4-deoxy-L-idu-4-enuronic acid]-R2

Synonyms

Ch'ase, Ch'ase ABC, chABC, chondroitinase ABC, chondroitinase ABC I, chondroitinase AC, ChS ABC lyase I, EC 4.2.2.4, EC 4.2.99.6

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.2 Acting on polysaccharides
                4.2.2.20 chondroitin-sulfate-ABC endolyase

Systematic Name

Systematic Name on EC 4.2.2.20 - chondroitin-sulfate-ABC endolyase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SYSTEMATIC NAME
IUBMB Comments
chondroitin-sulfate-ABC endolyase
This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta1-3)GalNAc(beta1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha1-3)GalNAc(beta1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [5]. The related enzyme EC 4.2.2.21, chondroitin-sulfate-ABC exolyase, has the same substrate specificity but removes disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments produced by EC 4.2.2.20 [4].