4.2.2.20: chondroitin-sulfate-ABC endolyase
This is an abbreviated version!
For detailed information about chondroitin-sulfate-ABC endolyase, go to the full flat file.
Word Map on EC 4.2.2.20
-
4.2.2.20
-
proteoglycans
-
glycosaminoglycans
-
heparan
-
dermatan
-
collagen
-
cartilage
-
hyaluronidase
-
cord
-
hyaluronic
-
heparitinase
-
cspgs
-
articular
-
4-sulfate
-
scar
-
nitrous
-
35ssulfate
-
decorin
-
alcian
-
aggrecan
-
keratanase
-
perineuronal
-
intervertebral
-
biglycan
-
iduronic
-
endo-beta-galactosidase
-
chemonucleolysis
-
monosulfated
-
chondroitin-4-sulfate
-
biotechnology
-
intradiscal
-
cetylpyridinium
-
neurocan
-
molecular biology
-
versican
-
chymopapain
-
fibrosus
-
sulfate-containing
-
hexasaccharide
-
unsulfated
-
medicine
-
6-sulphated
-
hemisection
-
wisteria
-
oversulfated
-
hexuronic
-
pulposus
-
stub
-
beta-d-xyloside
-
3hglucosamine
-
brevican
-
undersulfated
-
phosphacan
- 4.2.2.20
- proteoglycans
- glycosaminoglycans
- heparan
- dermatan
- collagen
- cartilage
- hyaluronidase
- cord
-
hyaluronic
- heparitinase
-
cspgs
-
articular
- 4-sulfate
- scar
-
nitrous
-
35ssulfate
- decorin
-
alcian
- aggrecan
- keratanase
-
perineuronal
-
intervertebral
- biglycan
-
iduronic
- endo-beta-galactosidase
-
chemonucleolysis
-
monosulfated
- chondroitin-4-sulfate
- biotechnology
-
intradiscal
-
cetylpyridinium
- neurocan
- molecular biology
- versican
- chymopapain
-
fibrosus
-
sulfate-containing
- hexasaccharide
-
unsulfated
- medicine
-
6-sulphated
-
hemisection
- wisteria
-
oversulfated
-
hexuronic
- pulposus
-
stub
-
beta-d-xyloside
-
3hglucosamine
- brevican
-
undersulfated
- phosphacan
Reaction
Synonyms
Ch'ase, Ch'ase ABC, chABC, chondroitinase ABC, chondroitinase ABC I, chondroitinase AC, ChS ABC lyase I, EC 4.2.2.4, EC 4.2.99.6
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Reference
Reference on EC 4.2.2.20 - chondroitin-sulfate-ABC endolyase
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Aguiarand, J.A.K.; Michelacci, Y.M.
Preparation and purification of Flavobacterium heparinum chondroitinases AC and B by hydrophobic interaction chromatography
Braz. J. Med. Biol. Res.
32
545-550
1999
Pedobacter heparinus
Hamai, A.; Hashimoto, N.; Mochizuki, H.; Kato, F.; Makiguchi, Y.; Horie, K.; Suzuki, S.
Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides
J. Biol. Chem.
272
9123-9130
1997
Proteus vulgaris
Asanbaeva, A.; Masuda, K.; Thonar, E.J.; Klisch, S.M.; Sah, R.L.
Mechanisms of cartilage growth. Modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC
Arthritis Rheum.
56
188-198
2007
Bos taurus
Huang, W.; Kuo, W.; Cherng, J.; Hsu, S.; Chen, P.; Huang, S.; Huang, M.; Liu, J.; Cheng, H.
Chondroitinase ABC promotes axonal re-growth and behavior recovery in spinal cord injury
Biochem. Biophys. Res. Commun.
349
963-968
2006
Rattus norvegicus
Graham, J.B.; Neubauer, D.; Xue, Q.; Muir, D.
Chondroitinase applied to peripheral nerve repair averts retrograde axonal regeneration
Exp. Neurol.
203
185-195
2007
Rattus norvegicus
Hermel, M.; Schrage, N.F.
Efficacy of plasmin enzymes and chondroitinase ABC in creating posterior vitreous separation in the pig: a masked, placebo-controlled in vivo study
Graefes Arch. Clin. Exp. Ophthalmol.
245
399-406
2007
Proteus vulgaris
Barritt, A.W.; Davies, M.; Marchand, F.; Hartley, R.; Grist, J.; Yip, P.; McMahon, S.B.; Bradbury, E.J.
Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury
J. Neurosci.
26
10856-10867
2006
Rattus norvegicus
Tester, N.J.; Plaas, A.H.; Howland, D.R.
Effect of body temperature on chondroitinase ABCs ability to cleave chondroitin sulfate glycosaminoglycans
J. Neurosci. Res.
85
1110-1118
2007
Proteus vulgaris
Zhang, Z.; Park, Y.; Kemp, M.M.; Zhao, W.; Im, A.R.; Shaya, D.; Cygler, M.; Kim, Y.S.; Linhardt, R.J.
Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern
Anal. Biochem.
385
57-64
2009
Pedobacter heparinus, Proteus vulgaris
Xia, Y.; Zhao, T.; Li, J.; Li, L.; Hu, R.; Hu, S.; Feng, H.; Lin, J.
Antisense vimentin cDNA combined with chondroitinase ABC reduces glial scar and cystic cavity formation following spinal cord injury in rats
Biochem. Biophys. Res. Commun.
377
562-566
2008
Proteus vulgaris
Massey, J.M.; Amps, J.; Viapiano, M.S.; Matthews, R.T.; Wagoner, M.R.; Whitaker, C.M.; Alilain, W.; Yonkof, A.L.; Khalyfa, A.; Cooper, N.G.; Silver, J.; Onifer, S.M.
Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3
Exp. Neurol.
209
426-445
2008
Proteus vulgaris
Tester, N.J.; Howland, D.R.
Chondroitinase ABC improves basic and skilled locomotion in spinal cord injured cats
Exp. Neurol.
209
483-496
2008
Proteus vulgaris
Garcia-Alias, G.; Lin, R.; Akrimi, S.F.; Story, D.; Bradbury, E.J.; Fawcett, J.W.
Therapeutic time window for the application of chondroitinase ABC after spinal cord injury
Exp. Neurol.
210
331-338
2008
Proteus vulgaris
Nielsen, T.C.; Meikle, P.J.; Hopwood, J.J.; Fuller, M.
Minimum substrate requirements of endoglycosidase activities toward dermatan sulfate by electrospray ionization-tandem mass spectrometry
Glycobiology
18
1119-1128
2008
Proteus vulgaris
Laparra, J.M.; Tako, E.; Glahn, R.P.; Miller, D.D.
Isolated glycosaminoglycans from cooked haddock enhance nonheme iron uptake by Caco-2 Cells
J. Agric. Food Chem.
56
10346-10351
2008
Proteus vulgaris
Mazzoni, A.; Pashley, D.H.; Ruggeri, A.J.; Vita, F.; Falconi, M.; Di Lenarda, R.; Breschi, L.
Adhesion to chondroitinase ABC treated dentin
J. Biomed. Mater. Res. B Appl. Biomater.
86B
228-236
2008
Proteus vulgaris
Hattori, T.; Matsuyama, Y.; Sakai, Y.; Ishiguro, N.; Hirata, H.; Nakamura, R.
Chondrotinase ABC enhances axonal regeneration across nerve gaps
J. Clin. Neurosci.
15
185-191
2008
Proteus vulgaris
Lin, R.; Kwok, J.C.; Crespo, D.; Fawcett, J.W.
Chondroitinase ABC has a long-lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain
J. Neurochem.
104
400-408
2008
Proteus vulgaris
Cafferty, W.B.; Bradbury, E.J.; Lidierth, M.; Jones, M.; Duffy, P.J.; Pezet, S.; McMahon, S.B.
Chondroitinase ABC-mediated plasticity of spinal sensory function
J. Neurosci.
28
11998-12009
2008
Proteus vulgaris
Hrabetova, S.; Masri, D.; Tao, L.; Xiao, F.; Nicholson, C.
Calcium diffusion enhanced after cleavage of negatively charged components of brain extracellular matrix by chondroitinase ABC
J. Physiol.
587
4029-4049
2009
Proteus vulgaris
Lee, H.; McKeon, R.J.; Bellamkonda, R.V.
Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury
Proc. Natl. Acad. Sci. USA
107
3340-3345
2010
Proteus vulgaris
Muir, E.; Fyfe, I.; Gardiner, S.; Li, L.; Warren, P.; Fawcett, J.; Keynes, R.; Rogers, J.
Modification of N-glycosylation sites allows secretion of bacterial chondroitinase ABC from mammalian cells
J. Biotechnol.
145
103-110
2010
Proteus vulgaris
Jefferson, S.C.; Tester, N.J.; Howland, D.R.
Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection
J. Neurosci.
31
5710-5720
2011
Proteus vulgaris
Klueppel, M.
Efficient secretion of biologically active chondroitinase ABC from mammalian cells in the absence of an N-terminal signal peptide
Mol. Cell. Biochem.
351
1-11
2011
Proteus vulgaris (P59807), Proteus vulgaris
Nazari-Robati, M.; Khajeh, K.; Aminian, M.; Mollania, N.; Golestani, A.
Enhancement of thermal stability of chondroitinase ABC I by site-directed mutagenesis: an insight from Ramachandran plot
Biochim. Biophys. Acta
1834
479-486
2013
Proteus vulgaris (P59807)
Chen, X.R.; Liao, S.J.; Ye, L.X.; Gong, Q.; Ding, Q.; Zeng, J.S.; Yu, J.
Neuroprotective effect of chondroitinase ABC on primary and secondary brain injury after stroke in hypertensive rats
Brain Res.
1543
324-333
2014
Proteus vulgaris
Nazari-Robati, M.; Khajeh, K.; Aminian, M.; Fathi-Roudsari, M.; Golestani, A.
Co-solvent mediated thermal stabilization of chondroitinase ABC I form Proteus vulgaris
Int. J. Biol. Macromol.
50
487-492
2012
Proteus vulgaris (P59807), Proteus vulgaris
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