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4.2.2.20: chondroitin-sulfate-ABC endolyase

This is an abbreviated version!
For detailed information about chondroitin-sulfate-ABC endolyase, go to the full flat file.

Word Map on EC 4.2.2.20

Reaction

R1-[beta-D-GalNAc-1,4-L-iduronic acid]-R2
=
R1-[beta-D-GalNAc]
+
[4-deoxy-L-idu-4-enuronic acid]-R2

Synonyms

Ch'ase, Ch'ase ABC, chABC, chondroitinase ABC, chondroitinase ABC I, chondroitinase AC, ChS ABC lyase I, EC 4.2.2.4, EC 4.2.99.6

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.2 Acting on polysaccharides
                4.2.2.20 chondroitin-sulfate-ABC endolyase

Engineering

Engineering on EC 4.2.2.20 - chondroitin-sulfate-ABC endolyase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Q140A
mutation improves both activity and thermal stability of the enzyme, and additionally improves resistance to trypsin degradation
Q140G
mutation improves both activity and thermal stability of the enzyme, and additionally improves resistance to trypsin degradation
Q140N
mutation reduces the enzyme activity and destabilizes
additional information