4.2.2.15: anhydrosialidase

This is an abbreviated version!
For detailed information about anhydrosialidase, go to the full flat file.

Word Map on EC 4.2.2.15

4.2.2.15

pneumoniae

sialic

pneumococci

macrobdella

leech

evasion

3.2.1.18

decora

fetuin

desialylation

sialoglycoconjugates

neuac

nakagawa

intranasal

synthesis

Reaction

2,7-anhydro-alpha-N-acetylneuraminic acid

Synonyms

alpha-(2,3)-specific trans-salidase, anhydroneuraminidase, EC 3.2.1.138, NanB, neuraminidase B, neuraminidase, anhydro-, sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing), sialidase L

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.2 Acting on polysaccharides

4.2.2.15 anhydrosialidase

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Results	in table
4	AA Sequence
1	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Crystallization (Commentary)
1	General Stability
1	Inhibitors
1	KM Value [mM]
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
5	Organism
1	PDB ID
1	pH Optimum
1	pI Value
2	Purification (Commentary)
1	Reaction
1	Reaction Type
5	Reference
1	Specific Activity [micromol/min/mg]
1	Storage Stability
8	Substrates and Products (Substrate)
2	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 4.2.2.15 - anhydrosialidase

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4-methylumbelliferyl-alpha-N-acetylneuraminic acid + H2O

4-methylumbelliferone + 2,7-anhydro-alpha-N-acetylneuraminic acid

3 entries

4-methylumbelliferyl-alpha-N-acetylneuraminic acid glycoproteins or ganglioside + H2O

2,7-anhydro-alpha-N-acetylneuraminic acid

3 entries

alpha-(2,3)-sialyl oligosacharides

Trypanosoma cruzi

648545

human alpha-1 acid glycoprotein + H2O

2,7-anhydro-alpha-N-acetylneuraminic acid + ?

Streptococcus pneumoniae

NanB preferentially cleaves alpha2-3 linked sialic acid from human alpha-1 glycoprotein

692359