4.2.2.1: hyaluronate lyase
This is an abbreviated version!
For detailed information about hyaluronate lyase, go to the full flat file.
Word Map on EC 4.2.2.1
-
4.2.2.1
-
streptococcus
-
chondroitin
-
disaccharide
-
glycosaminoglycans
-
agalactiae
-
chondroitinase
-
enteroaggregative
-
hyaluronidases
-
medicine
-
hyals
-
hyalurolyticus
-
pharmacology
-
autotransporter
-
degradation
-
synthesis
-
analysis
- 4.2.2.1
- streptococcus
- chondroitin
- disaccharide
- glycosaminoglycans
- agalactiae
- chondroitinase
-
enteroaggregative
- hyaluronidases
- medicine
-
hyals
-
hyalurolyticus
- pharmacology
-
autotransporter
- degradation
- synthesis
- analysis
Reaction
Synonyms
acidic hyase, bacterial HAse, bacterial hyaluronidase, bacterial spreading factor, bacteriophage-associated hyaluronate lyase, Cumulase, EC 4.2.99.1, GBS HA lyase, GBS hyase, glucuronoglycosaminoglycan lyase, h-SD, h-SH, HA lyase, HL, Hyal, Hyal-1, Hyal-2, HYAL1, Hyal2, HYAL3, hyaluronan lyase, hyaluronate lyase, hyaluronate lyase HylA, hyaluronate lyase HylP2, hyaluronidase, hyaluronidase 3, hyaluronidase SD, hyaluronidase SH, hyaluronidase-1, hyaluronidase-2, hyaluronoglucosaminidase-1, hyaluronoglucosaminidase-2, HYase, HylA7, hylB, hylB4755, HylP, Hylp2, LUCA-1, LUCA-2, lyase, glucuronoglycosaminoglycan, lyase, hyaluronate, More, mucinase, protein SEQ2045, rHuPH20, SagHL, SagHyal, spnHL, SpnHyal, spreading factor, SP_0314
ECTree
4.2.2.1 hyaluronate lyaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.2.2.1 - hyaluronate lyase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
chondroitin
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-galactosamine + ?
non-progressive mode
unsaturated disaccharide units
-
?
chondroitin sulfate
GlcA-(1-3)GalNAc(6-sulfate)-GlcA-(1-3)GalNAc(6-sulfate)-GlcA-(1-3)GalNAc(6-sulfate + GlcA-(1-3)GalNAc(6-sulfate)-GlcA-(1-3)GalNAc(6-sulfate)
-
-
-
-
?
chondroitin sulfate C
2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-galactose
hyaluronan
2-acetamido-2-deoxy-3-(beta-D-4-deoxy-gluco-4-enepyranosyluronic acid)-glucose + ?
-
-
-
-
?
hyaluronan
fully O-sulfated oligosaccharides
Streptomyces hyalurolyticus
-
from Streptococcus zooepidemicus, sodium salt, large scale depolymerization
chain length of 4-20, detection and composition analysis
-
?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
Streptomyces hyalurolyticus
-
from Streptococcus zooepidemicus, degradation
-
-
?
hyaluronan + H2O
oligosaccharides
-
specific for, degradation
-
-
?
hyaluronan tetrasaccharide
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
unsaturated disaccharide units
-
?
hyaluronate
?
-
efficient degradation of hyaluronate
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
hyaluronate hexasaccharide
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
unsaturated disaccharide
-
?
hyaluronic acid polymer
hyaluronic acid tetrasaccharide + hyaluronic acid hexasaccharide
Streptomyces hyalurolyticus
-
hyaluronic acid purified from Mytilus galloprovincialis
-
-
?
tetrasaccharides with a 6-sulfated disaccharide at the reducing end
?
-
-
-
-
?
chondroitin sulfate
?
degrades progressively unsulfated and 6-sulfated regions from the reducing end
-
-
?
chondroitin sulfate
?
non-progressive mode, no activity with chondroitin 4-sulfated at the nonreducing end, no activity with substrate sulfated at position 2
-
-
?
chondroitin sulfate A
?
-
24.7% of the activity with hyaluronate
-
-
?
chondroitin sulfate A
?
-
24.7% of the activity with hyaluronate
-
-
?
chondroitin sulfate C
2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-galactose
30% of the activity with hyaluronan
-
-
?
chondroitin sulfate C
2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-galactose
Neobacillus niacini JAM F8
30% of the activity with hyaluronan
-
-
?
hyaluronan
2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-glucose
enzyme displays endo-type degratation. The viscosity of hyaluronan decreases to 37% of the original one after 3-min incubation
-
-
?
hyaluronan
2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-glucose
Neobacillus niacini JAM F8
enzyme displays endo-type degratation. The viscosity of hyaluronan decreases to 37% of the original one after 3-min incubation
-
-
?
hyaluronan
2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-glucose
-
from human umbilical cord
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
from umbilical cord
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
enzyme might be involved in the pathogenicity of the bacterium causing paracocidiodomycosis
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
-
-
ir
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
unsaturated disaccharide
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
disaccharide unit
-
ir
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
elimination of the polymer in the host connective tissue
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
progressive degradation from the reducing end
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
substrate structure
disaccharide unit
-
ir
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
unsaturated disaccharide units
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
disaccharide unit
-
ir
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
degradation leads to increased permeability of the host tissue and therefore helps bacterial invasion
-
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
from human umbilical cord, degradation, from the reducing to the nonreducing end
unsaturated disaccharide units, product identification
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
progressive mode of action, degradation
unsaturated disaccharide unit
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
progressive mode, preferred substrate
unsaturated disaccharide units
-
?
hyaluronan
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
substrate structure
disaccharide unit
-
ir
hyaluronan
?
enzyme facilitates the invasion and spreading of the pathogenic bacterium in the host tissue by degrading the hosts' extracellular matrix component in connective tissue
-
-
?
hyaluronan
?
-
extracellular enzyme facilitates the invasion and spreading of the pathogenic bacterium in the host tissue by degrading the hosts' extracellular matrix component in connective tissue
-
-
?
hyaluronan
?
native enzyme and isolated N-terminal domain
-
-
?
hyaluronan
?
-
extracellular enzyme facilitates the invasion and spreading of the pathogenic bacterium in the host tissue by degrading the hosts' extracellular matrix component in connective tissue
-
-
?
hyaluronan
hyaluronic acid oligomers
-
absolute substrate specificity of the bacteriophage enzyme
-
-
?
hyaluronan
hyaluronic acid oligomers
-
absolute substrate specificity of the bacteriophage enzyme
-
-
?
hyaluronan hexasaccharide
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
progressive mode of action, degradation
unsaturated disaccharide unit
-
?
hyaluronan hexasaccharide
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
the longest segment that binds entirely within the active site, a cleft between alpha- and beta-domain
unsaturated disaccharide units
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
Streptomyces hyalurolyticus
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
eliminative reaction, degradation
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
3(DELTA-4,5-beta-D-glucuronosyl)-2-acetamido-2-deoxy-D-glucose
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
unsaturated disaccharide
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
-
-
?
hyaluronate
alpha-4-deoxy-L-threo-hex-4-enopyranosyluronic acid-beta-1,3--N-acetyl-glucosamine
-
-
unsaturated disaccharides are released from the end of the hyaluronan chains
?
hyaluronic acid
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
-
-
-
-
?
hyaluronic acid
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
Streptomyces hyalurolytics
-
from pig skin
-
-
?
hyaluronic acid
?
no activity against chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate
end-products are 4,5-unsaturated hyalurono-hexasaccharide and 4,5-unsaturated hyalurono-octasaccharide, with small amounts of 4,5-unsaturated hyalurono-tetrasaccharide, 4,5-unsaturated hyalurono-decasaccharide and longer oligosaccharides, early time points shows that a wide range of 4,5-unsaturated oligosaccharides are produced, indicating an endo-acting mode of digestion
-
?
hyaluronic acid
?
-
nonhydrolytic cleavage of the glycosidic bond, initiation of degradation activity analysis by molecular mechanical molecular dynamic simulations and free energy profiles, simulation and analysis of the enzyme-substrate complex structure, overview
-
-
?
hyaluronic acid
?
the enzyme is a hyaluronic acid specific hyaluronate lyase showing ability to degrade hyaluronate to unsaturated disaccharide units
-
-
?
hyaluronic acid
hyaluronic acid oligomers
-
degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor
-
-
?
hyaluronic acid
hyaluronic acid oligomers
-
degradation
-
-
?
hyaluronic acid
hyaluronic acid oligomers
-
degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor
-
-
?
hyaluronic acid
hyaluronic acid oligomers
-
degradation
-
-
?
hyaluronic acid
hyaluronic acid oligomers
-
degradation of hyaluronate in connective tissue of hosts to facilitate invasion
-
-
?
hyaluronic acid
hyaluronic acid oligomers
degradation of hyaluronate in connective tissue of hosts to facilitate invasion
-
-
?
hyaluronic acid
hyaluronic acid oligomers
degradation of hyaluronate in connective tissue of hosts to facilitate invasion
-
-
?
hyaluronic acid
hyaluronic acid oligomers
the enzyme is essential for growth on hyaluronate as carbon source
-
-
?
hyaluronic acid
hyaluronic acid oligomers
native and recombinant serotype 7 enzyme, human umbelical cord hyaluronate
-
-
?
hyaluronic acid
hyaluronic acid oligomers
Streptomyces hyalurolyticus
-
highly specific for hyaluronan, degradation, unsaturated products of varied size
-
-
?
hyaluronic acid
hyaluronic acid oligomers
Streptomyces hyalurolyticus
-
highly specific for hyaluronan
primarily disaccharides, but also tetrasaccharides and hexasaccharides
-
?
hyaluronic acid polymer
hyaluronic acid oligomers
-
degradation
-
-
?
hyaluronic acid polymer
hyaluronic acid oligomers
-
depolymerization
product identification by CE-MS, gel filtration, and viscosimetry
-
?
hyaluronic acid polymer
hyaluronic acid oligomers
-
degradation
-
-
?
hyaluronic acid polymer
hyaluronic acid oligomers
-
depolymerization
product identification by CE-MS, gel filtration, and viscosimetry
-
?
additional information
?
-
-
very poor substrate: chitosan. No substrates: heparin sodium, sodium alginate, carrageenan, pectin, soluble starch, xanthan gum
-
-
?
additional information
?
-
-
very poor substrate: chitosan. No substrates: heparin sodium, sodium alginate, carrageenan, pectin, soluble starch, xanthan gum
-
-
?
additional information
?
-
-
phylogenetic analysis, enzyme may play a role in releasing nutrients thereby promoting establishment of the organism in the gut
-
-
?
additional information
?
-
phylogenetic analysis, enzyme is the non-lethal Mu toxin, causes gas gangrene, produces many extracellular proteins during infection that are potetial virulence factors
-
-
?
additional information
?
-
chondroitin, 2.3% of the activity with hyaluronan
-
-
?
additional information
?
-
-
chondroitin, 2.3% of the activity with hyaluronan
-
-
?
additional information
?
-
Neobacillus niacini JAM F8
chondroitin, 2.3% of the activity with hyaluronan
-
-
?
additional information
?
-
-
the minimum recognition and digestion domain is hyaluronic acid heptasaccharide. The enzyme cleaves both beta-1,4- and beta-1,3-glycosidic linkages. The resulting oligosaccharides, generated with a 2-acetamido-2,3-di-deoxy-beta-D-erythro-hex-2-enopyranose at the non-reducing end, are believed to be unstable and undergo breakdown immediately after their generation, and oligosaccharides with a 4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid residue at the non-reducing end are formed
-
-
?
additional information
?
-
-
global regulators sar and agr are involved in enzyme regulation
-
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?
additional information
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global regulators sar and agr are involved in enzyme regulation
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additional information
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enzyme is a virulence factor that helps the pathogen to brake through the biophysical barrier of the host tissues
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additional information
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enzyme is a virulence factor that helps the pathogen to brake through the biophysical barrier of the host tissues
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additional information
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the enzyme contributes to the invasive capacity of the pathogenic organism by degrading hyaluronan and chondroitin sulfates of the extracellular matrix of host tissues
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additional information
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fragments from trypsin digestion are still active, enzyme is active in SDS-PAGE
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additional information
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the enzyme is involved in degradation of hyaluronate from connective host tissues to facilitate the host and specific tissue invasion by the bacterium, overview
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additional information
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the enzyme also catalyzes the degradation of other polymeric glycans
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additional information
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phylogenetic analysis, enzyme causes mastitis, may have an important role in promoting dissemination of the producing organism into host tissue
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additional information
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phylogenetic analysis, strong association between the production of purulent abscesses and enzyme during infections
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additional information
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phylogenetic analysis, causes a number of different infections, including meningitis and pneumoniae, where the enzyme may function as a spreading factor, while pneumolysin acts as a toxin
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additional information
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the enzyme is involved in degradation of hyaluronate from connective host tissues to facilitate the host and specific tissue invasion by the bacterium, overview
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additional information
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the enzyme also catalyzes the degradation of other polymeric glycans
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additional information
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C-terminal domain does not bind directly to the substrate, instead the domain contributes to the interaction with the polymeric hyaluronan for catalysis. Furthermore, the substrate specificity exchanges with the size of catalytic cleft. The role of linker connecting alpha-domain to C-terminal domain is found to hold the C-terminal domain in a conformation suitable for achieving maximum activity
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additional information
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mathematical model for the degradation of hyaluronan. The model is based on a processive kinetic mechanism and consists of a coupled system of nonlinear ordinary differential equations for the species of interest. The rate at which degradation proceeds is strongly dependent on the initial concentration of enzyme
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additional information
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phylogenetic analysis, anti-phagocytic factors, such as M-protein, might provide sufficient protection for Streptococcus pyogenes infection during enzyme production
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additional information
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substrate specificity, no activity with chonroitin, dermatan sulfate, keratan sulfate, heparin, chondroitin 4-sulfate and chondroitin 6-sulfate
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additional information
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substrate specificity, product indentification
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is a virulence factor of the animal pathogen, relation between enzyme activity, serotype, and disease state, overview
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additional information
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the enzyme is involved in development of meningitis in infected pigs
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additional information
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the enzyme is involved in development of meningitis in infected pigs
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additional information
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phylogenetic analysis, enzyme causes mastitis, may have an important role in promoting dissemination of the producing organism into host tissue, anti-phagocytic factors in the capsule, such as M-protein, might provide sufficient protection for Streptococcus pyogenes infection during enzyme production
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additional information
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Streptomyces hyalurolyticus
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hyaluronan is degraded by L-ascorbic acid, D-isoascorbic acid, and dehydroascorbic acid themselves, only slightly by L-gulonic-gamma-lactone, D-saccharic-1,4-lactone, and alpha-D-glucoheptonic-gamma-lactone
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