4.2.1.99: 2-methylisocitrate dehydratase

This is an abbreviated version!
For detailed information about 2-methylisocitrate dehydratase, go to the full flat file.

Reaction

Synonyms

(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate hydro-lyase, 2/2-methylisocitrate dehydratase, Dehydratase, 2-methylisocitrate

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.99 2-methylisocitrate dehydratase

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Results	in table
13389	AA Sequence
1	CAS Registry Number
1	Cofactor
4	Inhibitors
1	KM Value [mM]
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
5	Organism
6	Pathway
2	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
5	Reference
1	Specific Activity [micromol/min/mg]
6	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 4.2.1.99 - 2-methylisocitrate dehydratase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate

(Z)-But-2-ene-1,2,3-tricarboxylate + H2O

3 entries

(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate

?

2 entries

(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate

(Z)-But-2-ene-1,2,3-tricarboxylate + H2O

Yarrowia lipolytica

-

-

5947

-

-

?

(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate

(Z)-But-2-ene-1,2,3-tricarboxylate + H2O

Yarrowia lipolytica

-

r

5946

-

5946

?

(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate

(Z)-But-2-ene-1,2,3-tricarboxylate + H2O

Yarrowia lipolytica

-

no activity with: 2-methylcitrate, citrate, cis-aconitate, trans-aconitate, isocitrate

5946

-

5946

?

(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate

?

Yarrowia lipolytica

-

the enzyme is involved in methylcitric acid cycle for propionate metabolism

5946, 5947

-

-

?

(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate

?

Yarrowia lipolytica

-

constitutively synthesized, no regulatory function in the methylcitric acid cycle. The enzyme is supposed to have evolutionarily developed from a hypothetical and prototypical isocitrate dehydratase

5947

-

-

?